Summary

Name SLC24A1
Full Name Sodium/potassium/calcium exchanger 1
Synonyms Na(+)/K(+)/Ca(2+)-exchange protein 1, Retinal rod Na-Ca+K exchanger, Solute carrier family 24 member 1 | KIAA0702, NCKX1
Primary ID O60721
Links - -
Type protein
Relations 3
Function Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

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Relations

Regulator Mechanism target score ℹ
+ SLC24A1down-regulates quantity img/direct_inhibition.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ SLC24A1down-regulates quantity img/direct_inhibition.png relocalization potassium(1+) 0.8
Publications: 1 Organism: Homo Sapiens
+ SLC24A1up-regulates quantity img/direct-activation.png relocalization sodium(1+) 0.8
Publications: 1 Organism: Homo Sapiens