Summary

Name SLIT2
Full Name Slit homolog 2 protein
Synonyms Slit-2 | SLIL3
Primary ID O94813
Links - -
Type protein
Relations 6
Pathways Axon guidance
Function Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding GPC1 0.583
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding ROBO4 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ROBO2 0.858
Publications: 1 Organism: In Vitro
Pathways:Axon guidance
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLIT2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ROBO3 0.651
Publications: 1 Organism: In Vitro
Pathways:Axon guidance
+ up-regulates img/direct-activation.png binding ROBO 0.938
Publications: 1 Organism: In Vitro