Summary

Name PPBP
Full Name Platelet basic protein
Synonyms PBP, C-X-C motif chemokine 7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, Small-inducible cytokine B7 | CTAP3, CXCL7, SCYB7, TGB1, THBGB1
Primary ID P02775
Links - -
Type protein
Relations 2
Inhibitors PPBP
Function LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRM1 0.352
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition OPRD1 0.352
Publications: 1 Organism: Cricetulus Griseus