Summary

Name GSTA1
Full Name Glutathione S-transferase A1
Synonyms GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1 |
Primary ID P08263
Links - -
Type protein
Relations 4
Pathways Hepatocellular Tumor
Function Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GSTA1 0.354
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GSTA1 0.354
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor