Summary

Name CAPN2
Full Name Calpain-2 catalytic subunit
Synonyms Calcium-activated neutral proteinase 2, CANP 2, Calpain M-type, Calpain large polypeptide L2, Calpain-2 large subunit, Millimolar-calpain, M-calpain | CANPL2
Primary ID P17655
Links - -
Type protein
Relations 9
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CAPN2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAPN2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage MAPT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CDK5/CDK5R1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CAPN2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CDK5R1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage GSK3A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage GSK3B 0.14
Publications: 1 Organism: Homo Sapiens