| + |
MAPK1 | down-regulates activity 
phosphorylation
|
TFEB |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248279 |
Ser142 |
AGNSAPNsPMAMLHI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21617040 |
Evidence for ERK2-mediated TFEB phosphorylation came from ERK2-TFEB coimmuno-precipitation (fig. S12C) in normal but not in starved medium and from a peptide-based kinase assay showing that mutation of Ser142 to alanine abolished ERK2-mediated phosphorylation ( |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTOR | down-regulates activity
phosphorylation
|
TFEB |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255310 |
Ser142 |
AGNSAPNsPMAMLHI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22343943 |
Here, we have used an mTORC1 in-vitro kinase assay and a phosphoantibody to demonstrate that serine S142, which we previously found to be phosphorylated by ERK2, is also phosphorylated by mTOR and that this phosphorylation has a crucial role in controlling TFEB subcellular localization and activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248270 |
Ser211 |
LVGVTSSsCPADLTQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22692423 |
Our data points to the lysosome as the site where mTORC1-dependent phosphorylation of TFEB occurs. [...]Our study has revealed a specific role for phosphorylation of TFEB S211 in the negative regulation of the nuclear abundance of TFEB. This occurs through the promotion of 14-3-3 binding and the masking of the nearby NLS on TFEB. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
| + |
PPP3CB | up-regulates activity 
dephosphorylation
|
TFEB |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255307 |
Ser142 |
AGNSAPNsPMAMLHI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26000950 |
Lysosomal Ca2+ release via mucolipin 1 (MCOLN1) activates calcineurin, which binds and de-phosphorylates TFEB, thus promoting its nuclear translocation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255306 |
Ser211 |
LVGVTSSsCPADLTQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26000950 |
Lysosomal Ca2+ release via mucolipin 1 (MCOLN1) activates calcineurin, which binds and de-phosphorylates TFEB, thus promoting its nuclear translocation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | down-regulates activity
phosphorylation
|
TFEB |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255309 |
Ser142 |
AGNSAPNsPMAMLHI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22343943 |
Here, we have used an mTORC1 in-vitro kinase assay and a phosphoantibody to demonstrate that serine S142, which we previously found to be phosphorylated by ERK2, is also phosphorylated by mTOR and that this phosphorylation has a crucial role in controlling TFEB subcellular localization and activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248274 |
Ser211 |
LVGVTSSsCPADLTQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 22692423 |
Our data points to the lysosome as the site where mTORC1-dependent phosphorylation of TFEB occurs. [...]Our study has revealed a specific role for phosphorylation of TFEB S211 in the negative regulation of the nuclear abundance of TFEB. This occurs through the promotion of 14-3-3 binding and the masking of the nearby NLS on TFEB. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKCB | up-regulates activity
phosphorylation
|
TFEB |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255315 |
Ser466 |
SKASSRRsSFSMEEG |
Mus musculus |
|
| pmid |
sentence |
| 23599343 |
This occurs following PKCβ phosphorylation of TFEB on three serine residues located in its last 15 amino acids. This post-translational modification stabilizes and increases the activity of this transcription factor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255316 |
Ser467 |
KASSRRSsFSMEEGD |
Mus musculus |
Osteoclast |
| pmid |
sentence |
| 23599343 |
This occurs following PKCβ phosphorylation of TFEB on three serine residues located in its last 15 amino acids. This post-translational modification stabilizes and increases the activity of this transcription factor. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
3.0
TFEB
- 
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