Summary

Name COMT
Full Name Catechol O-methyltransferase
Synonyms COMT_HUMAN |
Primary ID P21964
Links - -
Type protein
Relations 8
Inhibitors entacapone; tolcapone
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

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Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png COMT 0.14
Publications: 1
+ up-regulates img/indirect-activation.png COMT 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COMT 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COMT 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition COMT 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition COMT 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation COMT 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COMT 0.14
Publications: 1 Organism: Homo Sapiens