Summary

Name FPR2
Full Name N-formyl peptide receptor 2
Synonyms FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP | FPRH1, FPRL1, LXA4R
Primary ID P25090
Links - -
Type protein
Relations 5
Function Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GNA14 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FPR2 0.555
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation FPR2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FPR2 0.631
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI3 0.404
Publications: 1 Organism: Homo Sapiens