Summary

Name HOXA9
Full Name Homeobox protein Hox-A9
Synonyms Homeobox protein Hox-1G | HOX1G
Primary ID P31269
Links - -
Type protein
Relations 17
Pathways AML-MLL, Acute Myeloid Leukemia, AML-ASXL1, AML-DNMT3A
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png methylation HOXA9
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown Differentiation
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-ASXL1, AML-DNMT3A, AML-MLL
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation HOXA9
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-MLL
+ up-regulates quantity by expression img/direct-activation.png methylation HOXA9 0.19
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-MLL
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression HOXA9 0.25
Publications: 1 Organism: Mus Musculus
Pathways:AML-MLL
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MEF2C 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYCN 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression HOXA9
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-ASXL1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression HOXA9 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-ASXL1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression HOXA9 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-DNMT3A
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation HOXA9 0.13
Publications: 1 Organism: Homo Sapiens
Pathways:AML-MLL
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HOXA9 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MEIS1 0.99
Publications: 1 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, AML-DNMT3A, AML-MLL
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HOXA9 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MSI2 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation HOXA9
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML-MLL
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGF1 0.02
Publications: 1 Organism: Homo Sapiens