| + |
KDM6A | up-regulates quantity by expression 
transcriptional regulation
|
HOXC13 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260027 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24561908 |
Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXC13 | up-regulates quantity by expression
transcriptional regulation
|
LAMB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261644 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10835276 |
The specificity of binding of these two proteins to the Lamin B2 origin is confirmed by both band-shift and in vitro footprinting assays. In addition, the ability of HOXC10 and HOXC13 to increase the activity of a promoter containing the 74 bp sequence, as assayed by CAT-assay experiments, demonstrates a direct interaction of these homeoproteins with the origin sequence in mammalian cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
HOXC13 | down-regulates quantity by repression 
transcriptional regulation
|
DSG4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254184 |
|
|
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 19683850 |
we studied the transcriptional regulation of DSG4 by transcription factors/pathways that are known regulators of hair keratin or KAP expression. We show that HOXC13, LEF1 and FOXN1 repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch pathway with the activation and/or maintenance of DSG4 expression in the hair follicle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXC13 | up-regulates quantity by expression 
transcriptional regulation
|
FOXN1 |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21191399 |
Hoxc13-dependent activation of foxn1 is part of a regulatory cascade controlling the expression of terminal differentiation markers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HOXC13
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