Summary

Name PEX19
Full Name Peroxisomal biogenesis factor 19
Synonyms 33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein | HK33, PXF
Primary ID P40855
Links - -
Type protein
Relations 1
Function Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding PEX19 0.953
Publications: 1 Organism: In Vitro