Summary

Name CD86
Full Name T-lymphocyte activation antigen CD86
Synonyms Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1 | CD28LG2
Primary ID P42081
Links - -
Type protein
Relations 2
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CD86 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD86 0.298
Publications: 1 Organism: Homo Sapiens