Summary

Name MEOX2
Full Name Homeobox protein MOX-2
Synonyms Growth arrest-specific homeobox, Mesenchyme homeobox 2 | GAX, MOX2
Primary ID P50222
Links - -
Type protein
Relations 3
Function Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding MEOX2 0.90
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MEOX2 0.76
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding MEOX2 0.42
Publications: 1 Organism: In Vitro