| + |
7a | down-regulates activity 
binding
|
BCL2L1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261075 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17428862 |
In this study, we show that the overexpression of Bcl-XL, a prosurvival member of the Bcl-2 family, blocks 7a-induced apoptosis, suggesting that the mechanism for apoptosis induction by 7a is at the level of or upstream from the Bcl-2 family. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS |
| + |
7a | up-regulates activity 
|
p38 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260754 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16378980 |
While there is a low level of activated p38 normally found in 293T cells, expression of 7a-protein stimulated larger amounts of activated p38 during the 24-h time course. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
| + |
7a | up-regulates
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260207 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16303160 |
Expression of SARS-CoV ORF7a block cell cycle arrest in G0/G1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
7a | up-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260197 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 15564512 |
7a induces apoptosis via a caspase-dependent pathway and in cell lines derived from different organs, including lung, kidney, and liver. | The overexpression of HA-tagged 7a (7a-HA) induces apoptosis in 293T (human kidney epithelial) cells, as evidenced by an increase in caspase-3 protease activity, a hallmark of apoptosis, which is comparable to that caused by the overexpression of BAX, a proapoptotic member of the Bcl-2 family |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260209 |
|
|
Chlorocebus aethiops |
Vero Cell |
| pmid |
sentence |
| 17686858 |
Cells expressing the ORF7a or ORF7b protein undergo apoptosis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION |
3.0
7a
- 
- 