Summary

Name E
Full Name Envelope small membrane protein
Synonyms E protein, sM protein | sM
Primary ID P59637
Links - -
Type protein
Relations 6
Pathways COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION, SARS-CoV ER STRESS
Function Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png relocalization SDCBP 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/indirect_inhibition.png ERN1 0.2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV ER STRESS
+ down-regulates activity img/indirect_inhibition.png BCL2L1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/indirect-activation.png NLRP3 inflammasome 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION, SARS-CoV ER STRESS
+ up-regulates activity img/indirect-activation.png p38 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Lung
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS, SARS-CoV MAPK PERTURBATION