Summary

Name CDC42
Full Name Cell division control protein 42 homolog
Synonyms G25K GTP-binding protein
Primary ID P60953
Links - -
Type protein
Relations 13
Pathways P38 Signaling and Myogenesis
Function Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CDC42 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown NFATC1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown MAPK14 0.20
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding PAK1 0.86
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PAK2 0.69
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding GSK3B 0.30
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDC42 0.50
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png relocalization USP6 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDC42 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDC42 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor CDC42 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PAK
Publications: 1 Organism: Mus Musculus