Summary

Name GRB10
Full Name Growth factor receptor-bound protein 10
Synonyms GRB10 adapter protein, Insulin receptor-binding protein Grb-IR | GRBIR, KIAA0207
Primary ID Q13322
Links - -
Type protein
Relations 17
Pathways FLT3 in AML
Function Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.28
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB10 0.28
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation GRB10 0.28
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation GRB10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GRB10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Mus Musculus
Pathways:FLT3 in AML
+ down-regulates img/direct_inhibition.png binding INSR 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB10 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding IGF1R 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding GRB10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ up-regulates img/direct-activation.png phosphorylation GRB10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB10 0.22
Publications: 1 Organism: Mus Musculus
Pathways:FLT3 in AML