Summary

Name TTF1
Full Name Transcription termination factor 1
Synonyms TTF-1, RNA polymerase I termination factor, Transcription termination factor I, TTF-I
Primary ID Q15361
Links - -
Type protein
Relations 1
Function Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding TTF1 0.318
Publications: 1 Organism: Homo Sapiens
Tissue: Lung