Summary

Name RSPO1
Full Name R-spondin-1
Synonyms Roof plate-specific spondin-1, hRspo1
Primary ID Q2MKA7
Links - -
Type protein
Relations 2
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png relocalization ZNRF3 0.796
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png relocalization ZNRF3 0.796
Publications: 1 Organism: Homo Sapiens