Summary

Name TIGIT
Full Name T-cell immunoreceptor with Ig and ITIM domains
Synonyms V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3 | VSIG9, VSTM3
Primary ID Q495A1
Links - -
Type protein
Relations 2
Function Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TIGIT 0.867
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARRB2 0.2
Publications: 1 Organism: Homo Sapiens