| Name
|
 TMEM97
|
| Full Name |
Sigma intracellular receptor 2 |
| Synonyms |
Sigma-2 receptor, Sigma2 receptor, Meningioma-associated protein 30, Transmembrane protein 97 | MAC30, S2R |
| Primary ID |
Q5BJF2 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588). |
3.0
chemical activation