Summary

Name HMBOX1
Full Name Homeobox-containing protein 1
Synonyms Homeobox telomere-binding protein 1, Telomere-associated homeobox-containing protein 1 | HOT1, TAH1
Primary ID Q6NT76
Links - -
Type protein
Relations 1
Function Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).

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Relations

Regulator Mechanism target score ℹ
+ HMBOX1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation IFNG 0.2
Publications: 1 Organism: Homo Sapiens