Summary

Name NLRX1
Full Name NLR family member X1
Synonyms Caterpiller protein 11.3, CLR11.3, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, Nucleotide-binding oligomerization domain protein 9 | NOD26, NOD5, NOD9
Primary ID Q86UT6
Links - -
Type protein
Relations 5
Function Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

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Relations

Regulator Mechanism target score ℹ
+ NLRX1up-regulates activity img/direct-activation.png binding PCBP2 0.416
Publications: 1 Organism: Homo Sapiens
+ NLRX1up-regulates activity img/indirect-activation.png relocalization NfKb-p65/p50 0.276
Publications: 1 Organism: Homo Sapiens
+ NLRX1up-regulates activity img/indirect-activation.png relocalization RELA 0.263
Publications: 1 Organism: Homo Sapiens
+ NLRX1down-regulates activity img/direct_inhibition.png binding TRAF6 0.488
Publications: 1 Organism: Homo Sapiens
+ NLRX1down-regulates activity img/direct_inhibition.png binding MAVS 0.745
Publications: 1 Organism: Homo Sapiens