| + |
Non-structural protein 10 |
binding
|
IFTAP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260251 |
|
|
Saccharomyces cerevisiae |
|
| pmid |
sentence |
| 18433331 |
In our previous work, we isolated a gene from a cDNA library of human embryo lung tissue, which en- coded a novel protein that specifically interacted with nsp-10 of SARS-CoV in a yeast trap experiment.|Since nsp- 10 of SARS-CoV is involved in viral genomic replica- tion and was observed to interact with ATF5, the cellular initiation factor of the RNA pol II complex (13), we in- ferred that HEPIS may also be involved in cellular gene transcription. Therefore, the significance of HEPIS ex- pression in cells needed to be further investigated. The work we describe here suggests that HEPIS represses cel- lular transcription initiation through interaction with a component of the RNA pol II complex |
|
| Publications: |
1 |
Organism: |
Saccharomyces Cerevisiae |
| + |
IFTAP | down-regulates activity 
binding
|
BTF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260252 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18433331 |
Furthermore, we co-immunoprecipitated HEPIS with BTF3, a component of the RNA pol II initiation complex, and observed reduced proliferation of HeLa cells transfected with the HEPIS gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IFTAP
- 
- 