Summary

Name LZTR1
Full Name Leucine-zipper-like transcriptional regulator 1
Synonyms LZTR-1 | TCFL2
Primary ID Q8N653
Links - -
Type protein
Relations 4
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png ubiquitination KRAS 0.254
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination KRAS 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LZTR1 0.278
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/indirect_inhibition.png LZTR1 0.2
Publications: 1 Organism: Homo Sapiens