Summary

Name DOT1L
Full Name Histone-lysine N-methyltransferase, H3 lysine-79 specific
Synonyms DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 | KIAA1814, KMT4
Primary ID Q8TEK3
Links - -
Type protein
Relations 9
Pathways MLL in AML
Function Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding DOT1L 0.14
Publications: 1 Organism: Mus Musculus
Pathways:MLL in AML
+ up-regulates activity img/direct-activation.png binding DOT1L 0.14
Publications: 1 Organism: Mus Musculus
Pathways:MLL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation MCL1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation HOXA9 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation MEIS1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ up-regulates activity img/direct-activation.png binding MYC 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ up-regulates activity img/direct-activation.png binding DOT1L 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:MLL in AML