| Name
|
 RUBCN
|
| Full Name |
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein |
| Synonyms |
Rubicon, Beclin-1 associated RUN domain containing protein, Baron | KIAA0226 |
| Primary ID |
Q92622 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745). |
3.0
binding