Summary

Name RUBCN
Full Name Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
Synonyms Rubicon, Beclin-1 associated RUN domain containing protein, Baron | KIAA0226
Primary ID Q92622
Links - -
Type protein
Relations 1
Function Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding PIK3C3 0.35
Publications: 1 Organism: Homo Sapiens