| + |
CRBN | down-regulates quantity by destabilization 
ubiquitination
|
IKZF3 |
0.607 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272319 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 29496670 |
IMiD compounds cause selective ubiquitination and degradation of IKZF1 in CD34+ cells by the CRBN E3 ubiquitin ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKZF3 | up-regulates quantity by expression 
transcriptional regulation
|
LNPEP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255405 |
|
|
Homo sapiens |
Trophoblast Cell Line |
| pmid |
sentence |
| 15894523 |
Activator protein-2 (AP-2) and Ikaros transcription factors play significant roles in exerting high promoter activity of P-LAP/OTase in the trophoblastic cells. Moreover, P-LAP/OTase is transcriptionally regulated in a trophoblast-differentiation-dependent fashion via up-regulation of AP-2, putatively AP-2alpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKZF3 | up-regulates activity
|
B_cell_maturation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259952 |
|
|
Mus musculus |
Lymphoid Progenitor Cell |
| pmid |
sentence |
| 14718515 |
Here we show that the Ikaros family member, Aiolos, is specifically required for the generation of these plasma cells. Failure to generate high affinity plasma cells in the BM and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos−/− mice with a range of hapten concentrations. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
lenalidomide | down-regulates quantity by destabilization
chemical inhibition
|
IKZF3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24328678 |
Members of the Ikaros family of transcription factors, specifically Ikaros and Aiolos (encoded by the genes IKZF1 and IKZF3 respectively), are recruited as protein substrates for CRL4CRBN in T cells in response to lenalidomide or pomalidomide treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IKZF3
- 
- 