Summary

Name FADS3
Full Name Fatty acid desaturase 3
Synonyms Delta(13) fatty acid desaturase, Delta(13) desaturase | CYB5RP
Primary ID Q9Y5Q0
Links - -
Type protein
Relations 2
Pathways Fatty Acid Synthesis
Function Mammals have different sphingoid bases that differ in their length and/or pattern of desaturation and hydroxyl groups. The predominant sphingoid base in mammalian ceramides is sphing-4-enine (sphingosine or SPH) which has a trans desaturation at carbon 4. FADS3 is a ceramide desaturase that introduces a cis double bond between carbon 14 and carbon 15 of the SPH-containing ceramides, producing sphinga-4,14-dienine-containing ceramides (SPD ceramides). SPD ceramides occur widely in mammalian tissues and cells. Due to their unusual structure containing a cis double bond, SPD ceramides may have an opposite, negative role in lipid microdomain formation relative to conventional ceramides (PubMed:31916624). FADS3 also acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 13 to generate (11E,13Z)-octadecadienoate (also known as conjugated linoleic acid 11E,13Z-CLA).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification long-chain fatty acyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates quantity img/direct-activation.png chemical modification arachidonoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis