| + |
IRAK3 | down-regulates activity 
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259288 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 12150927 |
IRAK-M(-/-) cells exhibited increased cytokine production upon TLR/IL-1 stimulation and bacterial challenge, and IRAK-M(-/-) mice showed increased inflammatory responses to bacterial infection. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IRAK3 | down-regulates 
binding
|
IRAK4 |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205434 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25290089 |
Irak3 exerts negative regulatory effects through preventing (i) the dissociation of irak1 and irak4 from myd88 irak3 negatively regulates irak signalling through suppression of irak4 and irak1 activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | up-regulates quantity 
transcriptional regulation
|
IRAK3 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259287 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25585690 |
We show that glucocorticoids and non-typeable Haemophilus influenzae synergistically upregulate IRAK-M expression via mutually and synergistically enhancing p65 and glucocorticoid receptor binding to the IRAK-M promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IRAK3
- 
- 