SIGNOR-AG Axon guidance ACTB ACTN1 ARHGDIA BAIAP2 CACNA1A CAMK2A CDC42 CFL1 DCC DSCAM ENAH EVL FSCN1 MYO10 NEO1 NTN1 PICK1 PLXNB3 PRKCA PRKG1 PTK2 RAC1 RAPH1 RGMA ROBO2 ROBO3 SEMA5A SLIT2 SRC UNC5A VASP SIGNOR-GBM Glioblastoma Multiforme BRAF CBL CREB1 EGF EGFR ELK1 GRB2 HRAS JUN KRAS NF1 PDPK1 PIK3CA PIK3R1 PTEN RASA1 SOS1 SIGNOR-RAS Retinoic acid Signaling ASCL1 CTNNB1 HES1 NEUROG1 NEUROG2 NOTCH1 RARA RARB RARG RXRA SIGNOR-AC Adipogenesis AKT1 CDK2 CEBPA CEBPB CEBPD CREB1 FOXO1 GATA2 GRB2 GSK3B INS INSR IRS1 KLF5 KRAS NR3C1 PDPK1 PIK3CB PPARG RAF1 RPS6KA5 SMAD3 SOS1 TGFB1 TGFBR1 SIGNOR-CC Circadian clock ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E DBP FASN NAMPT NFIL3 NPAS2 NR1D1 NR1D2 NR3C1 PER1 PER2 PER3 PPARA PPARG PPARGC1A RAI1 RORA RORB RORC SERPINE1 SIRT1 SIRT6 SREBF1 TIMELESS SIGNOR-PU Ubiquitin activation OTULIN UBA1 UBA6 UCHL3 USP5 USP7 USP9X SIGNOR-RAM Retinoic Acid Metabolism ALDH1A1 ALDH1A2 ALDH1A3 CYP26A1 DHRS9 RBP1 RBP2 RBP4 RDH10 RDH5 STRA6 SIGNOR-CB Carnitine biosynthesis ALDH9A1 BBOX1 SHMT1 TMLHE SIGNOR-FSGS Focal segmental glomerulosclerosis ACE AGT AGTR1 ITGB3 NFATC1 NPHS1 PAX2 PAXIP1 PLAUR REN TRPC6 SIGNOR-MD Mitochondrial dynamics in T cell exhaustion BRAF CALM1 CD274 CD28 CD4 CD8A CSK CTLA4 DNM1L EIF4E EIF4EBP1 FIS1 FYN GRB2 HRAS IL2 ITPR1 LAG3 LAT LCK LCP2 MFF MFN1 MFN2 MTFP1 MTOR NCK1 NFATC1 NFKBIA OPA1 PDCD1 PDPK1 PLCG1 PRKCA PTPRC RHEB RPTOR SOS1 ZAP70 SIGNOR-SHB Sex Hormone Biosynthesis CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP21A2 HSD17B11 HSD3B1 HSD3B2 STAR SIGNOR-VKC Vitamin-K cycle BGLAP CALU F10 F2 F7 F9 GAS6 GGCX PROC PROS1 PROZ VKORC1 SIGNOR-HPP Hippo Signaling CDH1 CTNNA1 NEDD4L NF2 SAV1 TJP2 WWC1 WWTR1 YAP1 SIGNOR-NS Noonan syndrome BRAF EGFR ELK1 GAB1 GRB2 HRAS KRAS NRAS PPP1CA PTPN11 RAF1 RIT1 SHC1 SHOC2 SOS1 SPRY1 SIGNOR-TI Transcription initiation POLR2A RRN3 UBTF SIGNOR-AAAM Aspartate and asparagine metabolism ADSS1 ADSS2 ASNS ASPA ASPG ATF4 CSAD GAD1 GAD2 GADL1 GOT1 GOT2 NAALAD2 NAT8L SIGNOR-PPP Pentose phosphate pathway DERA G6PD ME1 ME2 MYC NFE2L2 PGD PGLS PGM2 PRPS1 PRPS2 RBKS RPE RPEL1 RPIA SHPK TALDO1 TKT TP53 SIGNOR-Hedgehog Sonic Hedgehog ADCY1 DISP1 GLI1 GLI2 GLI3 GNAI2 GSK3B HHIP IHH KIF7 PRKACA PTCH1 SHH SMO SUFU SIGNOR-INSR Insulin Signaling EIF4E EIF4EBP1 FOXO3 GRB2 GSK3B GYS1 HRAS INS INSR IRS1 JUN PDPK1 PDX1 PIK3CB PTEN PTPN1 RAF1 RHEB RPS6KB1 SGK1 SOS1 SREBF1 TSC1 SIGNOR-CS Complement Signaling C2 C3 C3AR1 C4A C5 C5AR1 MASP1 MASP2 MBL2 SIGNOR-VEGF VEGF Signaling BAD BRAF CALM1 GRB2 HRAS ITPR1 KDR NOS3 PDPK1 PLCG1 PRKCA PTK2 PXN SOS1 VEGFA VEGFC VEGFD SIGNOR-FattyAcidSynthesis Fatty Acid Synthesis ACACA ACACB ACLY ACSL1 ACSL5 CPT1A FADS1 FADS2 FADS3 FADS6 FASN MDH1 ME1 SLC25A1 SIGNOR-FapINS FAP: Insulin-mediated adipogenesis DLK1 FOXA2 FOXO1 GATA2 INS INSR PDPK1 PPARG SIGNOR-DS Dopaminergic Synapse ADCY5 BDNF CDK5 CREB1 DRD1 DRD2 DRD3 DRD4 DRD5 GNAL GNAQ GNB5 ITPR1 PLCB1 PPP1CA PPP1R1B SIGNOR-TLR Toll like receptors IKBKE IRAK1 IRF3 MAP2K3 MAP2K6 MAP2K7 MAP3K1 MAP3K7 MAP3K8 MAPK14 MAPK8 MYD88 NFKBIA SARM1 TBK1 TICAM1 TICAM2 TIRAP TRAF6 SIGNOR-GS Glutamatergic synapse ACTN1 ADCY1 ANKS1B CAMK2A DLG4 DLGAP1 GNAS ITPR1 NLGN1 PLCB1 SHANK1 SHANK3 SYNGAP1 SIGNOR-M1M2 Macrophage polarization IFNG IL10 IL10RA IL13 IL4 IL4R IRF4 JAK2 KDM6B MAP2K4 MAP3K1 MAPK8 PPARG RIPK1 SOCS1 STAT3 STAT6 TICAM1 TICAM2 TLR4 SIGNOR-IIS Innate Immune Response DDX1 DDX21 DDX28 DDX58 DHX30 EIF2AK2 G3BP1 G3BP2 IFIH1 IKBKE IRAK1 IRF3 IRF7 MAP3K14 MAVS MYD88 RIPK1 STING1 TBK1 TICAM1 TIRAP TRAF3 TRAF6 SIGNOR-MCAPO Mitochondrial Control of Apoptosis APAF1 BAD BAX BBC3 BCL2 BCL2L1 BCL2L11 BID CASP3 CASP8 CASP9 CYCS FADD FAS FASLG NOXA1 PARP1 RIPK1 TNF TNFRSF1A TP53 TRADD SIGNOR-TC Thyroid cancer BRAF CTNNB1 FOXO3 GRB2 KRAS MYC PDPK1 PPARG PTEN RET SHC1 SLC5A5 SOS1 TG TGFB1 TGFBR1 TPO TSHB SIGNOR-GSP GABAergic synapse ADCY1 ARHGEF9 BDNF CACNA1B CREB1 GABARAP GNB5 GPHN NLGN2 SLC12A2 SLC12A5 SIGNOR-LR Leptin Signaling ACACA AGRP EGR1 FOS FOXO1 INS INSR IRS1 JAK2 LEP LEPR MC4R MTOR NPY POMC PPARG PTPN11 SH2B1 SOCS3 STAT3 STAT5A SIGNOR-IL6 IL6 Signaling BRAF CTF1 ELK1 GRB2 IL6 IL6R IL6ST JAK1 LIFR NRAS PIAS3 SHC1 SOCS1 SOCS3 SOS1 SRC STAT3 SIGNOR-MSP Multiple sclerosis ACVR1B ACVR2A ACVR2B CD40 IFNG IL10 IL10RA IL17A IL1B IL4 IL4R IL6 IL6R IL6ST INHBA JAK1 NFKBIA RIPK1 SMAD2 SMAD3 STAT3 TGFBR1 TGFBR2 TNF TNFRSF1A TNFRSF21 TRAF2 SIGNOR-B-cell B-cell activation BLK BLNK BTK CALM1 CD19 CD22 CD79A CD79B DOK3 FYN GRB2 INPP5D LAT LYN NFATC1 NFATC2 PDPK1 PLCG1 PLCG2 PRKCA PTEN SH2B1 STAT5A SYK SIGNOR-VDM Vitamin-D Metabolism CYP24A1 CYP27B1 CYP2R1 GC SIGNOR-P38 P38 Signaling CREB1 DDIT3 DUSP1 LCK MAP2K3 MAP2K4 MAP2K6 MAP3K4 MAP3K5 MAP3K7 MAPK14 MAPKAPK2 MAPT PPM1A PPM1D PTCRA RPS6KA5 STAT1 TAB1 TAOK1 TAOK2 TGFB1 TGFBR1 TNF TNFRSF1A TP53 TRADD TRAF2 TRAF6 USF1 ZAP70 SIGNOR-OKIP Chemokines PDAC AXL CCL5 CCR5 CD274 CSF2 CSF2RA CXCL1 CXCL2 CXCL3 CXCL5 CXCL8 CXCR1 CXCR2 DDR1 FOXP3 GAS6 IL6 JAK2 STAT5A SIGNOR-NSCLCN Non-small-cell lung cancer (NSCLC) BAK1 BCL2 BRAF EGF EGFR GRB2 HRAS IGF1R KRAS PDPK1 RASSF1 SOS1 TGFA TP53 SIGNOR-PC Prostate Cancer AR ERG EZH2 FOXA1 HDAC1 HGF MDM2 MET MYC NCOA2 NCOA3 NKX3-1 PDPK1 PIK3CA PPARG PTEN SPOP TMPRSS2 TP53 UBE2C SIGNOR-FM One-carbon Metabolism DHFR MTHFD1 MTHFR MTR SFXN1 SHMT1 SHMT2 TYMS SIGNOR-CAC Citric acid cycle ACLY ACO1 ACO2 CS FH MDH1 MDH2 SIGNOR-LBC Luminal Breast Cancer BRAF CDKN2A CYP19A1 E2F1 ESR1 FGF1 FGFR1 FRS2 GRB2 INS INSR IRS1 JUN KRAS MDM2 PDPK1 PIK3CA PTEN RB1 RHEB SOS1 TP53 SIGNOR-IA myCAF signaling in PDAC ACTA2 CCN2 COL1A1 COL1A2 SMAD2 SMAD3 TEAD4 TGFB1 TGFB2 TGFBR1 TGFBR2 YAP1 ZFYVE9 SIGNOR-AML Acute Myeloid Leukemia ASXL1 ASXL2 BAD BAK1 BAX BCL2 BCL2L1 BCOR BCORL1 BRAF CBL CBLB CCNA1 CCND1 CDK1 CDK6 CDKN1A CDKN1B CDKN2A CEBPA CEBPB CTBP1 CTNNB1 CUX1 DNMT3A DOT1L DVL1 EGFR EP300 ETV6 EZH2 FBXW7 FLT3 FLT3LG FOS FZD4 GRB10 GRB2 GSK3B HES1 HHEX HOXA9 ID1 IDH1 IDH2 IGF1 INPP5D JAK2 JUN KAT5 KDM5A KIT KITLG KLF2 KRAS MAPK8 MCL1 MDM2 MECOM MECP2 MEIS1 MEN1 MTOR MYC NCOA1 NCOR2 NOTCH1 NPM1 NRAS PARP1 PAX7 PDPK1 PHF6 PIK3IP1 PIM1 PTEN PTGS2 PTPN11 PTPN6 PTPRC PTPRJ RAC1 RAD21 RAD51 RARA RELA RUNX1 RXRA SH2B3 SHC1 SIRT1 SNW1 SOS1 SOX4 SP1 SPI1 SRSF2 STAT3 STAT5A TET2 TP53 TWIST1 UBTF USP22 WT1 ZBTB16 SIGNOR-Fibrosis Fibrosis ACE ACE2 AGT AGTR1 AGTR2 Angiotensin-1 Angiotensin 1-7 Angiotensin-2 BCL2L11 EP300 MAS1 REN SERPINE1 SMAD3 SMAD7 TGFBR1 TGFBR2 SIGNOR-P38_Myogenesis P38 Signaling and Myogenesis ABL1 ADAM17 AKT1 AKT2 BNIP2 CDC42 CDH15 CDON EZH2 IGF1 IGF1R KHSRP MAP2K3 MAP2K4 MAP2K6 MAP3K5 MAP3K7 MAPK14 MEF2A MEF2C MEF2D MYOD1 MYOG RIPK1 SMARCD3 SPAG9 TAB2 TCF3 TNF TNFRSF1A SIGNOR-G2-M_trans Cell cycle: G2/M phase transition ABL1 ATM ATR BRCA1 BUB1 CDC25A CDKN1A CDKN1B CDKN2A CHEK1 CHEK2 E2F1 GSK3B HIPK2 MDM2 MYC PRKDC RAD51 RAD52 RB1 SMAD3 TP53 SIGNOR-YTS YAP/TAZ regulation ABL1 ACTN1 AMOT CDK1 CDK8 CSNK1D CSNK1E CTNNA1 CTNNB1 DDX17 ERBB4 GNA13 GSK3B LATS1 MTOR NF2 NLK NUAK2 PPP2CA PTK2 RHEB RHOA RUNX1 RUNX2 SAV1 SMAD2 SMAD3 SRC STK11 TP73 WBP2 WWTR1 YAP1 YES1 SIGNOR-DR Death Receptor Signaling APAF1 BAX BCL2 BID CASP3 CASP8 CASP9 CYCS DIABLO FADD FAS FASLG PARP1 RIPK1 TNF TNFRSF1A TRADD XIAP SIGNOR-NFKBC NF-KB Canonical CYLD FADD FAS FASLG ITCH MAP3K7 NFKBIA RIPK1 RNF11 TAB2 TAB3 TAX1BP1 TNF TNFAIP3 TNFRSF1A TRADD TRAF2 TRAF6 UBE2N UBE2V1 SIGNOR-CRC Colorectal Carcinoma ATM BCL2 BRAF CTNNB1 ERBB2 GRB2 IGF1R IGF2 IRS2 KRAS LEF1 LRP5 MYC PIK3CA PTEN SMAD3 SMAD4 SOS1 TGFB1 TGFBR1 TP53 WNT1 SIGNOR-Glycolysis Glycolysis and Gluconeogenesis CRTC2 FBP1 GAPDH GAPDHS GPI LDHA PC PCK1 PCK2 PDK1 PFKFB3 SLC25A1 SLC2A1 SLC2A3 SLC2A4 TP53 TPI1 SIGNOR-AMPK AMPK Signaling CREB1 FOXO3 INS INSR IRS1 PDPK1 PFKFB2 PIK3CA PPARGC1A RHEB RPS6KA1 SIRT1 STK11 STRADA SIGNOR-TCA T cell activation BRAF CALM1 CD28 CD4 CD8A CSK CTTN FYN GRB2 HRAS LAT LCK LCP2 NCK1 NFATC1 NFKBIA PAK1 PDPK1 PLCG1 PRKCA PTPRC SOS1 ZAP70 SIGNOR-THM Thyroid Hormone Metabolism ADCY1 CALM1 CAMK4 CAMKK2 CGA CREB1 CREBBP DIO1 DIO2 DIO3 GATA2 GNA11 GNAQ GNAS IFNG IL1B IRF9 IYD LHX3 NKX2-1 PAX8 PLCB1 POU1F1 PRKCA SLC16A2 SLC5A5 SMAD3 TG TGFB1 TGFBR1 THRA THRB TNF TPO TRH TRHR TSHB TSHR UBE2G2 UBE2J1 WWTR1 SIGNOR-M Macropinocytosis ADCY10 ALS2 ARF6 CDC42 GRB2 HRAS INPP5B KRAS LGALS3 OCRL PAK1 RAB21 RAB5A RAB7A RAC1 RHOA SOS1 SIGNOR-RMS Rhabdomyosarcoma BRAF CDKN1A CDKN2A CTNNB1 FGF1 FGFR4 FOXO1 GAB1 GRB2 HGF IGF1 IGF1R IGF2 KRAS MET MYC MYOD1 MYOG PAX3 PAX7 PDGFA PDGFB PDGFRA PDPK1 PIK3CA RB1 SOS1 SRC STAT3 TBX2 SIGNOR-ReS Rett syndrome BDNF BRAF CDKL5 CREB1 DLL1 DLX5 DNMT1 FKBP5 GAD1 GAMT GPRIN1 GRB2 GRIA2 HIPK2 HRAS IGFBP3 MECP2 MEF2C MTOR NOTCH1 NTRK2 PPARG PTPN1 RELN SHC3 SOS1 TET2 SIGNOR-mRNA_Maturation mRNA maturation PABPC1 PAPOLA RAMAC RNGTT RNMT TUT4 TUT7 SIGNOR-NFKBNC NF-KB Non Canonical BIRC2 CD40 CD40LG CHUK LTB LTBR MAP3K14 NFKB2 RELB TNFRSF13C TNFSF13B TRAF2 TRAF3 SIGNOR-EI EBV infection BGLF4 BGLF5 BLLF1 BPLF1 BRLF1 BZLF1 BZLF2 CD19 CR2 CSK EBNA1 gH gL HLA-DRA HLA-DRB1 IFNB1 IGF1 IGF1R IKBKG IRF3 IRF7 JAK1 JAK2 LF2 LMP1 LMP2 LYN MAP3K1 MAP3K7 MAP4K1 MYD88 NFKBIA SMAD2 STAT1 STAT3 TBK1 TGFB1 TICAM1 TIRAP TLR2 TLR9 TNF TP53 TRAF6 TYK2 UBE2I USP7 SIGNOR-Glycogenolysis Glycogenolysis PGM1 PGM2 PHKA1 PHKA2 PHKG1 PHKG2 SIGNOR-TCIP Tenascin-C in PDAC CCND1 CDKN1B CTNNB1 FOXO1 PTK2 TNC SIGNOR-Autophagy Autophagy AMBRA1 ATG10 ATG12 ATG14 ATG3 ATG4B ATG7 BCL2 BECN1 GABARAP GABARAPL1 GABARAPL2 MAP1LC3C PIK3C3 SOD1 SQSTM1 UVRAG SIGNOR-MS MTOR Signaling AKT1S1 EIF4E EIF4EBP1 GSK3B INS INSR IRS1 MTOR PDPK1 PIK3CA PIK3R1 PPARG PPARGC1A PTEN RHEB RPS6 RPS6KA1 RPS6KB1 RPTOR SREBF1 TFEB ULK1 SIGNOR-AD Alzheimer APAF1 APP BAX BCL2 BID CAPN1 CASP3 CASP8 CAST CDK5R1 CYCS FADD GSK3A GSK3B MAPT NAE1 NCSTN PSEN1 PSEN2 TNF TNFRSF1A TRADD SIGNOR-G1-S_trans Cell cycle: G1/S phase transition ATM ATR CDC25A CDKN1A CDKN1B CDKN2A CHEK2 E2F1 GSK3B MDM2 MYC RB1 SMAD3 TP53 SIGNOR-CM Catecholamine metabolism COMT CYP2D6 DBH DDC MAOA PAH PNMT TH TPH1 SIGNOR-TEAT Translation elongation and termination AARS1 ABCE1 CARS1 EEF1A1 EEF2 GARS1 HARS1 NARS1 SARS1 TARS1 VARS1 WARS1 YARS1 SIGNOR-TGFb TGF-beta Signaling ATF2 CDKN2B FKBP1A MAP2K3 MAP2K4 MAP2K6 MAP3K7 MAPK14 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 TGFB1 TGFB2 TGFBR1 TGFBR2 TRAF6 ZFYVE9 SIGNOR-PDAP Pancreatic ductal adenocarcinoma (PDA) BRAF CDK4 CDKN2A CDKN2B CTNNB1 E2F1 EGF EGFR FHIT KRAS MDM2 NFKBIA RB1 SMAD2 SMAD3 SMAD4 STAT3 TERT TGFA TGFBR1 TGFBR2 TP53 VEGFA SIGNOR-GP Glutamine metabolism ASNS CAD CPS1 GFPT1 GLS GLS2 GLUD1 GLUL GMPS GOT1 GOT2 GPT2 PPAT SIRT4 SLC1A5 SLC38A1 SLC38A2 SIGNOR-IS Integrin Signaling CDKN1B DOK1 ELK1 FOXO3 GRB2 HRAS ILK ITGB1 ITGB1BP1 ITGB3 ITGB4 PTK2 PXN RAF1 SOS1 SRC TLN1 WWTR1 YAP1 SIGNOR-Inflammosome Inflammosome Activation CCL2 EIF2AK2 GSDMD IL18 IL1B IRF3 JAK1 MAP3K7 MYD88 RIPK1 TBK1 TICAM1 TNF TRAF3 TRAF6 TYK2 SIGNOR-WNT_Myogenesis WNT Signaling and Myogenesis ADCY1 CREB1 CTNNB1 DAAM1 DVL1 GNAS JUN LEF1 LRP5 LRP6 MAPK8 MYF5 MYOD1 PAX3 PITX2 PRKACA RAC1 RHOA ROCK1 WNT1 WNT11 WNT3A WNT5A WNT7A SIGNOR-PD Parkinson AKT1 CASP3 CASP9 CYCS DNAJC14 HTRA2 LRRK2 MTOR PINK1 PRKN SNCA UBC UCHL1 XIAP SIGNOR-IAIP iCAF signaling in PDAC AXL CCL2 CSF1 CSF1R CXCL1 CXCL2 CXCL3 CXCL8 CXCR2 GAS6 IL10 IL10RA IL11 IL1A IL1B IL1R1 IL1RAP IL1RL1 IL2 IL2RB IL2RG IL33 IL34 IL6 IL6R IL6ST JAK1 JAK3 LIF MAP3K7 STAT3 STAT5A TNF SIGNOR-EGF EGFR Signaling BRAF CBLB EGF EGFR ELK1 ERRFI1 FOS GAB1 GRB2 HRAS JAK2 JUN MAP2K4 MAP3K1 MAPK8 MYC NCK1 PAK1 PDPK1 PIK3CA PTPN11 SHC1 SOS1 SRC STAT3 SIGNOR-NM Nucleotide Biosynthesis ADK ADSL ADSS1 ADSS2 ATIC CAD CPS1 DHODH GART GMPS IMPDH1 IMPDH2 MAPK1 MYC NFE2L2 PAICS PFAS PPAT RPS6KB1 UMPS SIGNOR-IL1R IL1 Signaling BIRC3 IL1A IL1B IL1R1 IL1RAP IL1RN IRAK1 IRAK4 MAP3K7 MYD88 NFKBIA PELI1 TAB2 TOLLIP TRAF6 SIGNOR-TA TNF-alpha Signaling BAG4 BAX BID CASP3 CASP8 FADD JUN MAP2K3 MAP2K4 MAP2K7 MAP3K1 MAP3K5 MAPK14 MAPK8 NFKBIA PARP1 RIPK1 TNF TNFRSF1A TRADD TRAF2 SIGNOR-SAPK-JNK SAPK/JNK Signaling ATF2 BAX BCL2L11 CRK ELK1 GRB2 JUN MAP2K4 MAP2K6 MAP3K1 MAP3K7 MAP4K1 MAP4K2 MAPK8 MAPK8IP1 NFATC2 RIPK1 SH3RF1 SMAD3 TNFRSF1B TRAF1 TRAF2 YWHAZ SIGNOR-G Glycogenesis GBE1 GYS1 GYS2 PGM1 PGM2 UGP2 SIGNOR-IoT Initiation of Translation EIF1 EIF2B1 EIF2S1 EIF4B EIF5 EIF5B EIF6 SIGNOR-PI3K-AKT PI3K/AKT Signaling BRAF CREB1 EIF4E EIF4EBP1 GAB1 GRB2 GSK3B GYS1 HRAS MKNK1 PDPK1 PPP2CA PTEN SOS1 SIGNOR-OS Oxytocin signaling CAPRIN2 CD38 CREB1 CREB3L1 DRD2 ESR1 ESR2 GNAI1 GNAQ GNAS GNB5 GRK2 HRAS ITPR1 LNPEP Neurophysin 1 OXT OXTR Oxytocin PAM PCSK2 PCSK5 PLCB1 PLCE1 RAF1 RARA RARB TAC1 THRA SIGNOR-MM Malignant Melanoma BAD BAK1 BAX BCL2 BCL2L1 BRAF CDKN2A CREB1 E2F1 GRB2 KIT KITLG MDM2 MITF NRAS PDPK1 PIK3CA PTEN RB1 RPS6KA5 SOS1 TP53 SIGNOR-GCR Glucocorticoid receptor Signaling HNF4A HSP90AA1 JUN MAPK1 MAPK14 MAPK3 MAPK8 NCOA1 NFKB1 NR3C1 STAT5A SIGNOR-WNT WNT Signaling ADCY1 CREB1 CSNK1A1 CTNNB1 DAAM1 DKK1 DVL1 GNAS JUN LEF1 LRP5 LRP6 MAPK8 MYC PRKACA RAC1 RHOA ROCK1 SFRP1 WNT1 WNT11 WNT3A WNT5A WNT7A SIGNOR-NOTCH NOTCH Signaling ADAM17 DLK1 DLL1 DLL3 DLL4 DTX1 HES1 HEY1 HIF1A JAG1 JAG2 KDM5A MIB1 MYOD1 NFKB1 NOTCH1 NRARP VEGFA YY1 SIGNOR-IOA Inhibition of Apoptosis BAD BAX BCL2 BCL2L11 BRAF CASP3 CASP7 CASP9 CREB1 FOXO1 FOXO3 GRB2 MAP3K7 NFKBIA NRAS PARP1 RPS6KA1 SOS1 TNF TNFRSF1A TRADD TRAF2 XIAP SIGNOR-NR Neurotransmitters release ADCY1 APBA1 CACNA1A CAMK2A CSNK2A1 CTNNB1 DAPK1 DNM1 GNAI1 ITPR1 NRXN1 RAB3A RIMS1 SCRIB SNAP25 SNCA SNX9 STON2 STX1A STXBP1 SV2A SYBU SYN1 SYP SYT1 UNC13B VAMP2 SIGNOR-HT Hepatocellular Tumor BRAF CTNNB1 DVL1 EGFR GAB1 GRB2 GSTA1 HGF HMOX1 HRAS IGF1R IGF2 KEAP1 LEF1 MET MYC NFE2L2 NQO1 PDPK1 PTEN SMAD2 SMAD3 SMAD4 SOS1 TCF4 TERT TGFA TGFBR1 TGFBR2 SIGNOR-NOTCH_Myogenesis NOTCH Signaling and Myogenesis ADAM17 DLK1 DLL1 DTX1 DUSP1 HES1 HEY1 MAPK14 MEF2C MYOD1 MYOG NOTCH1 NRARP NUMB PAX7