| Name | APBB1 |
| ID | O00213 |
| Role | substrate |
| Enzymatic Domains |
WW 253-285 PROSITE-ProRule
PID 1 370-509 PROSITE-ProRule
PID 2 542-699 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | APBB1 | Ser175 | EEEEDLSsPPGLPEP | phosphorylation unknown | 14697653 | SIGNOR-120467 |
| ERK1/2 | APBB1 | – | phosphorylation unknown | 14697653 | SIGNOR-270166 | |
| SGK1 | APBB1 | Ser610 | ECRVRFLsFLAVGRD | phosphorylation down-regulates activity | 26188042 | SIGNOR-278220 |
| MAPK1 | APBB1 | Ser347 | TFPAQSLsPEPLPQE | phosphorylation unknown | 14697653 | SIGNOR-120459 |
| Gbeta | APBB1 | – | phosphorylation unknown | 14697653 | SIGNOR-270054 | |
| GSK3B | APBB1 | Thr579 | SSSREQWtPSHVSVA | phosphorylation up-regulates quantity | 28963516 | SIGNOR-278359 |
| MAPK3 | APBB1 | Ser287 | WEPPGRAsPSQGSSP | phosphorylation unknown | 14697653 | SIGNOR-120475 |
| MAPK3 | APBB1 | Ser347 | TFPAQSLsPEPLPQE | phosphorylation unknown | 14697653 | SIGNOR-120479 |
| ABL1 | APBB1 | Tyr547 | VQKFQVYyLGNVPVA | phosphorylation up-regulates | 15031292 | SIGNOR-123476 |
| MAPK1 | APBB1 | Ser287 | WEPPGRAsPSQGSSP | phosphorylation unknown | 14697653 | SIGNOR-120455 |
| MAPK1 | APBB1 | Thr709 | PKRLGAHtP | phosphorylation unknown | 14697653 | SIGNOR-120463 |
| MAPK3 | APBB1 | Thr709 | PKRLGAHtP | phosphorylation unknown | 14697653 | SIGNOR-120483 |
| MAPK1 | APBB1 | Ser175 | EEEEDLSsPPGLPEP | phosphorylation unknown | 14697653 | SIGNOR-120451 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | APBB1 PSer175 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120467 |
| SGK1 | phosphorylation up-regulates → | APBB1 PSer610 | phosphorylation down-regulates ⊣ | APBB1 | 26188042 | SIGNOR-278220 |
| MAPK1 | phosphorylation up-regulates → | APBB1 PSer347 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120459 |
| GSK3B | phosphorylation up-regulates → | APBB1 PThr579 | phosphorylation up-regulates → | APBB1 | 28963516 | SIGNOR-278359 |
| MAPK3 | phosphorylation up-regulates → | APBB1 PSer287 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120475 |
| MAPK3 | phosphorylation up-regulates → | APBB1 PSer347 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120479 |
| ABL1 | phosphorylation up-regulates → | APBB1 PTyr547 | phosphorylation up-regulates → | APBB1 | 15031292 | SIGNOR-123476 |
| MAPK1 | phosphorylation up-regulates → | APBB1 PSer287 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120455 |
| MAPK1 | phosphorylation up-regulates → | APBB1 PThr709 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120463 |
| MAPK3 | phosphorylation up-regulates → | APBB1 PThr709 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120483 |
| MAPK1 | phosphorylation up-regulates → | APBB1 PSer175 | phosphorylation down-regulates ⊣ | APBB1 | 14697653 | SIGNOR-120451 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → unknown | APBB1 | SIGNOR-120467 |
| ERK1/2 | phosphorylation → unknown | APBB1 | SIGNOR-270166 |
| SGK1 | phosphorylation → down-regulates activity | APBB1 | SIGNOR-278220 |
| MAPK1 | phosphorylation → unknown | APBB1 | SIGNOR-120459 |
| Gbeta | phosphorylation → unknown | APBB1 | SIGNOR-270054 |
| GSK3B | phosphorylation → up-regulates quantity | APBB1 | SIGNOR-278359 |
| MAPK3 | phosphorylation → unknown | APBB1 | SIGNOR-120475 |
| MAPK3 | phosphorylation → unknown | APBB1 | SIGNOR-120479 |
| ABL1 | phosphorylation → up-regulates | APBB1 | SIGNOR-123476 |
| MAPK1 | phosphorylation → unknown | APBB1 | SIGNOR-120455 |
| MAPK1 | phosphorylation → unknown | APBB1 | SIGNOR-120463 |
| MAPK3 | phosphorylation → unknown | APBB1 | SIGNOR-120483 |
| MAPK1 | phosphorylation → unknown | APBB1 | SIGNOR-120451 |