Summary

Name APBB1
Full Name Amyloid-beta A4 precursor protein-binding family B member 1
Synonyms Protein Fe65 | FE65, RIR
Primary ID O00213
Links - -
Type protein
Relations 9
Function Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation APBB1 0.14
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation APBB1 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation APBB1 0.14
Publications: 1 Organism: Homo Sapiens