| Name | ARNTL |
| ID | O00327 |
| Role | substrate |
| Enzymatic Domains |
bHLH 72-125 PROSITE-ProRule
PAS 1 143-215 PROSITE-ProRule
PAS 2 326-396 PROSITE-ProRule
PAC 401-444 |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | ARNTL | Ser17 | STISDFMsPGPTDLL | phosphorylation down-regulates | 20049328 | SIGNOR-162786 |
| GSK3B | ARNTL | Thr21 | DFMSPGPtDLLSSSL | phosphorylation down-regulates | 20049328 | SIGNOR-162790 |
| AKT2 | ARNTL | – | phosphorylation down-regulates activity | 27576939 | SIGNOR-280177 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | ARNTL PSer17 | phosphorylation down-regulates ⊣ | ARNTL | 20049328 | SIGNOR-162786 |
| GSK3B | phosphorylation up-regulates → | ARNTL PThr21 | phosphorylation down-regulates ⊣ | ARNTL | 20049328 | SIGNOR-162790 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates | ARNTL | SIGNOR-162786 |
| GSK3B | phosphorylation down-regulates | ARNTL | SIGNOR-162790 |
| AKT2 | phosphorylation → down-regulates activity | ARNTL | SIGNOR-280177 |