Summary

Name ARNTL
Full Name Aryl hydrocarbon receptor nuclear translocator-like protein 1
Synonyms Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, bHLHe5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3 | BHLHE5, BMAL1, MOP3, PASD3
Primary ID O00327
Links - -
Type protein
Relations 25
Pathways Circadian clock
Function Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARNTL 0.382
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ARNTL 0.317
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER1 0.734
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.686
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ARNTL 0.668
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRY2 0.933
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.4
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARA 0.594
Publications: 1 Organism: Mus Musculus
Tissue: Liver
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER3 0.573
Publications: 1
Pathways:Circadian clock
+ form complex img/form-complex.png binding CLOCK/BMAL1 0.78
Publications: 1 Organism: In Vitro
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.502
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.668
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.478
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.747
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.516
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRY1 0.933
Publications: 1
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding MAGEL2 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.594
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.467
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation VWF 0.324
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.342
Publications: 1 Organism: Mus Musculus