Summary

Name ARNTL
Full Name Aryl hydrocarbon receptor nuclear translocator-like protein 1
Synonyms Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, bHLHe5, Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3 | BHLHE5, BMAL1, MOP3, PASD3
Primary ID O00327
Links - -
Type protein
Relations 24
Pathways Circadian clock
Function Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARNTL 0.396
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARA 0.576
Publications: 1 Organism: Mus Musculus
Tissue: Liver
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.488
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.498
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.678
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER1 0.718
Publications: 1
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ARNTL 0.661
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.522
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ARNTL 0.661
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.732
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.497
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER3 0.589
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.411
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ARNTL 0.325
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRY2 0.932
Publications: 1
Pathways:Circadian clock
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation VWF 0.334
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CRY1 0.932
Publications: 1
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding MAGEL2 0.382
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.576
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ form complex img/form-complex.png binding CLOCK/BMAL1 0.765
Publications: 1 Organism: In Vitro
Pathways:Circadian clock