| Name | EEF2K |
| ID | O00418 |
| Role | kinase |
| Enzymatic Domains |
Alpha-type protein kinase 116-326 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EEF2K | EEF2K | Ser445 | SGDSGYPsEKRGELD | phosphorylation down-regulates | 22669845 | SIGNOR-197725 |
| EEF2K | EEF2 | Thr57 | RAGETRFtDTRKDEQ | phosphorylation down-regulates | 12194824 | SIGNOR-91751 |
| EEF2K | EEF2 | Thr59 | GETRFTDtRKDEQER | phosphorylation down-regulates | 2261989 | SIGNOR-22928 |
| EEF2K | EEF2 | Thr57 | RAGETRFtDTRKDEQ | phosphorylation down-regulates | 8386634 | SIGNOR-38552 |
| EEF2K | EEF2 | Thr59 | GETRFTDtRKDEQER | phosphorylation down-regulates | 8386634 | SIGNOR-38556 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EEF2K | phosphorylation up-regulates → | EEF2K PSer445 | phosphorylation down-regulates ⊣ | EEF2K | 22669845 | SIGNOR-197725 |
| EEF2K | phosphorylation up-regulates → | EEF2 PThr57 | phosphorylation down-regulates ⊣ | EEF2 | 12194824 | SIGNOR-91751 |
| EEF2K | phosphorylation up-regulates → | EEF2 PThr59 | phosphorylation down-regulates ⊣ | EEF2 | 2261989 | SIGNOR-22928 |
| EEF2K | phosphorylation up-regulates → | EEF2 PThr57 | phosphorylation down-regulates ⊣ | EEF2 | 8386634 | SIGNOR-38552 |
| EEF2K | phosphorylation up-regulates → | EEF2 PThr59 | phosphorylation down-regulates ⊣ | EEF2 | 8386634 | SIGNOR-38556 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EEF2K | phosphorylation down-regulates | EEF2K | SIGNOR-197725 |
| EEF2K | phosphorylation down-regulates | EEF2 | SIGNOR-91751 |
| EEF2K | phosphorylation down-regulates | EEF2 | SIGNOR-22928 |
| EEF2K | phosphorylation down-regulates | EEF2 | SIGNOR-38552 |
| EEF2K | phosphorylation down-regulates | EEF2 | SIGNOR-38556 |