Summary

Name EEF2K
Full Name Eukaryotic elongation factor 2 kinase
Synonyms eEF-2 kinase, eEF-2K, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Primary ID O00418
Links - -
Type protein
Relations 30
Function Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.28
Publications: 2 Organism: Homo Sapiens, In Vitro
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.22
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.08
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.22
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.08
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.08
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.08
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.22
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.08
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.22
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.28
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EEF2 0.37
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination EEF2K 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EEF2K 0.08
Publications: 1 Organism: Homo Sapiens