Summary

Name EEF2K
Full Name Eukaryotic elongation factor 2 kinase
Synonyms eEF-2 kinase, eEF-2K, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Primary ID O00418
Links - -
Type protein
Relations 32
Function Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K 0.75
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.75
Publications: 2 Organism: Homo Sapiens, In Vitro
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.54
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.89
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EEF2K 0.85
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.59
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K 0.86
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation EEF2K
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation EEF2K
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.64
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEF2K
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEF2K 0.88
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EEF2 1.00
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination EEF2K 0.77
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EEF2K 0.82
Publications: 1 Organism: Homo Sapiens