| Name | EEF2K |
| ID | O00418 |
| Role | substrate |
| Enzymatic Domains |
Alpha-type protein kinase 116-326 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | EEF2K | Ser74 | ERYSSSGsPANSFHF | phosphorylation down-regulates activity | 35513296 | SIGNOR-277907 |
| PRKACA | EEF2K | Ser500 | RLHLPRAsAVALEVQ | phosphorylation up-regulates activity | 11171059 | SIGNOR-250444 |
| RPS6KA1 | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 11500364 | SIGNOR-109708 |
| MAPK13 | EEF2K | Ser359 | GTEEKCGsPQVRTLS | phosphorylation down-regulates | 18337751 | SIGNOR-177986 |
| PRKAA1 | EEF2K | Ser78 | SSGSPANsFHFKEAW | phosphorylation down-regulates activity | 14709557 | SIGNOR-250314 |
| MAPK14 | EEF2K | Ser396 | TFDSLPSsPSSATPH | phosphorylation down-regulates activity | 12171600 | SIGNOR-249707 |
| mTORC1 | EEF2K | Ser72 | KSERYSSsGSPANSF | phosphorylation down-regulates activity | 35513296 | SIGNOR-277906 |
| PRKAA2 | EEF2K | Ser78 | SSGSPANsFHFKEAW | phosphorylation down-regulates activity | 14709557 | SIGNOR-250321 |
| PRKAA2 | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 14709557 | SIGNOR-250319 |
| mTORC1 | EEF2K | Ser70 | LTKSERYsSSGSPAN | phosphorylation down-regulates activity | 35513296 | SIGNOR-277908 |
| PRKAA1 | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 14709557 | SIGNOR-250402 |
| CDK1 | EEF2K | Ser359 | GTEEKCGsPQVRTLS | phosphorylation down-regulates | 18337751 | SIGNOR-177982 |
| MAPKAPK2 | EEF2K | Ser377 | PPLLRPLsENSGDEN | phosphorylation unknown | 12171600 | SIGNOR-249710 |
| MAPK13 | EEF2K | Ser359 | GTEEKCGsPQVRTLS | phosphorylation down-regulates activity | 11500363 | SIGNOR-109703 |
| TRPM7 | EEF2K | Ser78 | SSGSPANsFHFKEAW | phosphorylation up-regulates activity | 21112387 | SIGNOR-277923 |
| EEF2K | EEF2K | Ser445 | SGDSGYPsEKRGELD | phosphorylation down-regulates | 22669845 | SIGNOR-197725 |
| mTORC1 | EEF2K | Tyr69 | NLTKSERySSSGSPA | phosphorylation down-regulates activity | 35513296 | SIGNOR-277909 |
| RPS6KB1 | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 11500364 | SIGNOR-109712 |
| MAPK13 | EEF2K | Ser396 | TFDSLPSsPSSATPH | phosphorylation down-regulates activity | 11500363 | SIGNOR-250089 |
| RPS6K | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation down-regulates activity | 11500364 | SIGNOR-252775 |
| MAPK12 | EEF2K | Ser396 | TFDSLPSsPSSATPH | phosphorylation unknown | 12171600 | SIGNOR-250137 |
| PRKAA1 | EEF2K | Ser398 | DSLPSSPsSATPHSQ | phosphorylation up-regulates activity | 14709557 | SIGNOR-250157 |
| AMPK | EEF2K | Ser398 | DSLPSSPsSATPHSQ | phosphorylation up-regulates | 22669845 | SIGNOR-216503 |
| p38 | EEF2K | – | phosphorylation down-regulates activity | 12171600 | SIGNOR-270127 | |
| PRKAA1 | EEF2K | Ser398 | DSLPSSPsSATPHSQ | phosphorylation up-regulates | 22669845 | SIGNOR-197734 |
| PRKAA2 | EEF2K | Ser398 | DSLPSSPsSATPHSQ | phosphorylation up-regulates activity | 14709557 | SIGNOR-250158 |
| MAPKAPK5 | EEF2K | Ser377 | PPLLRPLsENSGDEN | phosphorylation unknown | 12171600 | SIGNOR-249708 |
| PRKACA | EEF2K | Ser366 | SPQVRTLsGSRPPLL | phosphorylation up-regulates activity | 11171059 | SIGNOR-250354 |
| MAPKAPK3 | EEF2K | Ser377 | PPLLRPLsENSGDEN | phosphorylation unknown | 12171600 | SIGNOR-249709 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | phosphorylation up-regulates → | EEF2K PSer74 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277907 |
| PRKACA | phosphorylation up-regulates → | EEF2K PSer500 | phosphorylation up-regulates → | EEF2K | 11171059 | SIGNOR-250444 |
| RPS6KA1 | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 11500364 | SIGNOR-109708 |
| MAPK13 | phosphorylation up-regulates → | EEF2K PSer359 | phosphorylation down-regulates ⊣ | EEF2K | 18337751 | SIGNOR-177986 |
| PRKAA1 | phosphorylation up-regulates → | EEF2K PSer78 | phosphorylation down-regulates ⊣ | EEF2K | 14709557 | SIGNOR-250314 |
| MAPK14 | phosphorylation up-regulates → | EEF2K PSer396 | phosphorylation down-regulates ⊣ | EEF2K | 12171600 | SIGNOR-249707 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PSer72 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277906 |
| PRKAA2 | phosphorylation up-regulates → | EEF2K PSer78 | phosphorylation down-regulates ⊣ | EEF2K | 14709557 | SIGNOR-250321 |
| PRKAA2 | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 14709557 | SIGNOR-250319 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PSer70 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277908 |
| PRKAA1 | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 14709557 | SIGNOR-250402 |
| CDK1 | phosphorylation up-regulates → | EEF2K PSer359 | phosphorylation down-regulates ⊣ | EEF2K | 18337751 | SIGNOR-177982 |
| MAPKAPK2 | phosphorylation up-regulates → | EEF2K PSer377 | phosphorylation down-regulates ⊣ | EEF2K | 12171600 | SIGNOR-249710 |
| MAPK13 | phosphorylation up-regulates → | EEF2K PSer359 | phosphorylation down-regulates ⊣ | EEF2K | 11500363 | SIGNOR-109703 |
| TRPM7 | phosphorylation up-regulates → | EEF2K PSer78 | phosphorylation up-regulates → | EEF2K | 21112387 | SIGNOR-277923 |
| EEF2K | phosphorylation up-regulates → | EEF2K PSer445 | phosphorylation down-regulates ⊣ | EEF2K | 22669845 | SIGNOR-197725 |
| mTORC1 | phosphorylation up-regulates → | EEF2K PTyr69 | phosphorylation down-regulates ⊣ | EEF2K | 35513296 | SIGNOR-277909 |
| RPS6KB1 | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 11500364 | SIGNOR-109712 |
| MAPK13 | phosphorylation up-regulates → | EEF2K PSer396 | phosphorylation down-regulates ⊣ | EEF2K | 11500363 | SIGNOR-250089 |
| RPS6K | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation down-regulates ⊣ | EEF2K | 11500364 | SIGNOR-252775 |
| MAPK12 | phosphorylation up-regulates → | EEF2K PSer396 | phosphorylation down-regulates ⊣ | EEF2K | 12171600 | SIGNOR-250137 |
| PRKAA1 | phosphorylation up-regulates → | EEF2K PSer398 | phosphorylation up-regulates → | EEF2K | 14709557 | SIGNOR-250157 |
| AMPK | phosphorylation up-regulates → | EEF2K PSer398 | phosphorylation up-regulates → | EEF2K | 22669845 | SIGNOR-216503 |
| PRKAA1 | phosphorylation up-regulates → | EEF2K PSer398 | phosphorylation up-regulates → | EEF2K | 22669845 | SIGNOR-197734 |
| PRKAA2 | phosphorylation up-regulates → | EEF2K PSer398 | phosphorylation up-regulates → | EEF2K | 14709557 | SIGNOR-250158 |
| MAPKAPK5 | phosphorylation up-regulates → | EEF2K PSer377 | phosphorylation down-regulates ⊣ | EEF2K | 12171600 | SIGNOR-249708 |
| PRKACA | phosphorylation up-regulates → | EEF2K PSer366 | phosphorylation up-regulates → | EEF2K | 11171059 | SIGNOR-250354 |
| MAPKAPK3 | phosphorylation up-regulates → | EEF2K PSer377 | phosphorylation down-regulates ⊣ | EEF2K | 12171600 | SIGNOR-249709 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277907 |
| PRKACA | phosphorylation → up-regulates activity | EEF2K | SIGNOR-250444 |
| RPS6KA1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-109708 |
| MAPK13 | phosphorylation down-regulates | EEF2K | SIGNOR-177986 |
| PRKAA1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-250314 |
| MAPK14 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-249707 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277906 |
| PRKAA2 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-250321 |
| PRKAA2 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-250319 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277908 |
| PRKAA1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-250402 |
| CDK1 | phosphorylation down-regulates | EEF2K | SIGNOR-177982 |
| MAPKAPK2 | phosphorylation → unknown | EEF2K | SIGNOR-249710 |
| MAPK13 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-109703 |
| TRPM7 | phosphorylation → up-regulates activity | EEF2K | SIGNOR-277923 |
| EEF2K | phosphorylation down-regulates | EEF2K | SIGNOR-197725 |
| mTORC1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-277909 |
| RPS6KB1 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-109712 |
| MAPK13 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-250089 |
| RPS6K | phosphorylation → down-regulates activity | EEF2K | SIGNOR-252775 |
| MAPK12 | phosphorylation → unknown | EEF2K | SIGNOR-250137 |
| PRKAA1 | phosphorylation → up-regulates activity | EEF2K | SIGNOR-250157 |
| AMPK | phosphorylation → up-regulates | EEF2K | SIGNOR-216503 |
| p38 | phosphorylation → down-regulates activity | EEF2K | SIGNOR-270127 |
| PRKAA1 | phosphorylation → up-regulates | EEF2K | SIGNOR-197734 |
| PRKAA2 | phosphorylation → up-regulates activity | EEF2K | SIGNOR-250158 |
| MAPKAPK5 | phosphorylation → unknown | EEF2K | SIGNOR-249708 |
| PRKACA | phosphorylation → up-regulates activity | EEF2K | SIGNOR-250354 |
| MAPKAPK3 | phosphorylation → unknown | EEF2K | SIGNOR-249709 |