| Name | DVL2 |
| ID | O14641 |
| Role | substrate |
| Enzymatic Domains |
DIX 11-93 PROSITE-ProRule
PDZ 267-339 PROSITE-ProRule
DEP 433-507 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | DVL2 | Ser143 | FHPNVSSsHENLEPE | phosphorylation up-regulates | 22609948 | SIGNOR-197547 |
| CSNK1E | DVL2 | – | phosphorylation up-regulates activity | 10517632 | SIGNOR-244097 | |
| RIPK4 | DVL2 | Ser298 | DGGIYIGsIMKGGAV | phosphorylation up-regulates activity | 23371553 | SIGNOR-279756 |
| PTEN | DVL2 | Ser143 | FHPNVSSsHENLEPE | dephosphorylation down-regulates activity | 26399523 | SIGNOR-277035 |
| CSNK1E | DVL2 | Thr224 | MSRFSSStEQSSASR | phosphorylation up-regulates | 22609948 | SIGNOR-197555 |
| RIPK4 | DVL2 | Ser480 | REARKYAsGLLKAGL | phosphorylation up-regulates activity | 23371553 | SIGNOR-279757 |
| CSNK1D | DVL2 | Thr224 | MSRFSSStEQSSASR | phosphorylation up-regulates | 22609948 | SIGNOR-197551 |
| PLK1 | DVL2 | Thr206 | MTSELEStSLGDSDE | phosphorylation up-regulates | 20823832 | SIGNOR-167858 |
| CSNK1E | DVL2 | Ser143 | FHPNVSSsHENLEPE | phosphorylation up-regulates | 22609948 | SIGNOR-197063 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | phosphorylation up-regulates → | DVL2 PSer143 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197547 |
| RIPK4 | phosphorylation up-regulates → | DVL2 PSer298 | phosphorylation up-regulates → | DVL2 | 23371553 | SIGNOR-279756 |
| PTEN | dephosphorylation down-regulates ⊣ | DVL2 PSer143 | dephosphorylation up-regulates → | DVL2 | 26399523 | SIGNOR-277035 |
| CSNK1E | phosphorylation up-regulates → | DVL2 PThr224 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197555 |
| RIPK4 | phosphorylation up-regulates → | DVL2 PSer480 | phosphorylation up-regulates → | DVL2 | 23371553 | SIGNOR-279757 |
| CSNK1D | phosphorylation up-regulates → | DVL2 PThr224 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197551 |
| PLK1 | phosphorylation up-regulates → | DVL2 PThr206 | phosphorylation up-regulates → | DVL2 | 20823832 | SIGNOR-167858 |
| CSNK1E | phosphorylation up-regulates → | DVL2 PSer143 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197063 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation → up-regulates | DVL2 | SIGNOR-197547 |
| CSNK1E | phosphorylation → up-regulates activity | DVL2 | SIGNOR-244097 |
| RIPK4 | phosphorylation → up-regulates activity | DVL2 | SIGNOR-279756 |
| PTEN | dephosphorylation → down-regulates activity | DVL2 | SIGNOR-277035 |
| CSNK1E | phosphorylation → up-regulates | DVL2 | SIGNOR-197555 |
| RIPK4 | phosphorylation → up-regulates activity | DVL2 | SIGNOR-279757 |
| CSNK1D | phosphorylation → up-regulates | DVL2 | SIGNOR-197551 |
| PLK1 | phosphorylation → up-regulates | DVL2 | SIGNOR-167858 |
| CSNK1E | phosphorylation → up-regulates | DVL2 | SIGNOR-197063 |