| + |
CSNK1E | up-regulates 
phosphorylation
|
DVL2 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197063 |
Ser143 |
FHPNVSSsHENLEPE |
Homo sapiens |
|
| pmid |
sentence |
| 22609948 |
We demonstrated that dvl2 is phosphorylated at s143 and t224 in a manner that requires both non-canonical wnt5a ligand and casein kinase 1 epsilon (ck1_), and that this event is critical to interact with plk1 in early stages of the cell cycle |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197555 |
Thr224 |
MSRFSSStEQSSASR |
Homo sapiens |
|
| pmid |
sentence |
| 22609948 |
We demonstrated that dvl2 is phosphorylated at s143 and t224 in a manner that requires both non-canonical wnt5a ligand and casein kinase 1 epsilon (ck1_), and that this event is critical to interact with plk1 in early stages of the cell cycle |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK1D | up-regulates
phosphorylation
|
DVL2 |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197547 |
Ser143 |
FHPNVSSsHENLEPE |
Homo sapiens |
|
| pmid |
sentence |
| 22609948 |
Ck1_/__dependent phosphorylation of dvl2 at s143 and t224and that this event is critical to interact with plk1 in early stages of the cell cycle |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197551 |
Thr224 |
MSRFSSStEQSSASR |
Homo sapiens |
|
| pmid |
sentence |
| 22609948 |
Ck1_/__dependent phosphorylation of dvl2 at s143 and t224and that this event is critical to interact with plk1 in early stages of the cell cycle |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTEN | down-regulates activity 
dephosphorylation
|
DVL2 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277035 |
Ser143 |
FHPNVSSsHENLEPE |
Homo sapiens |
|
| pmid |
sentence |
| 26399523 |
This showed that while both PTEN WT and the lipid phosphatase-inactive G129E mutant suppressed phosphorylation of DVL2 on serine 143 that accumulated upon PTEN knockdown, the C124S and Y138L mutants did not .|Finally, it is important to point out that while our studies show that PTEN can directly dephosphorylate DVL2 in vitro, it is possible that regulation of serine 143 phosphorylation of DVL2 by PTEN in cells may require additional protein factors, or post-translational modifications. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RIPK4 | up-regulates activity
phosphorylation
|
DVL2 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279756 |
Ser298 |
DGGIYIGsIMKGGAV |
Homo sapiens |
|
| pmid |
sentence |
| 23371553 |
Co-transfection of a RIPK4-GFP fusion increased the percentage of cells containing DVL2 puncta to more than 75% ( and ), suggesting that RIPK4 facilitates DVL2 signalosome formation.|Phosphorylation of DVL2 at Ser 298 and Ser 480 by RIPK4 favored canonical Wnt signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279757 |
Ser480 |
REARKYAsGLLKAGL |
Homo sapiens |
|
| pmid |
sentence |
| 23371553 |
Co-transfection of a RIPK4-GFP fusion increased the percentage of cells containing DVL2 puncta to more than 75% ( and ), suggesting that RIPK4 facilitates DVL2 signalosome formation.|Phosphorylation of DVL2 at Ser 298 and Ser 480 by RIPK4 favored canonical Wnt signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates
phosphorylation
|
DVL2 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167858 |
Thr206 |
MTSELEStSLGDSDE |
Homo sapiens |
|
| pmid |
sentence |
| 20823832 |
Dvl2 bound to and was phosphorylated at thr206 by a mitotic kinase, polo-like kinase 1 (plk1), and this phosphorylation was required for spindle orientation and stable microtubule (mt)-kt attachment |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | up-regulates
binding
|
GSK3B/Axin/APC |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227920 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17529994 |
Dishevelled (dvl) transduces the wnt signal by interacting with the cytoplasmic axin complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD2 | up-regulates activity
binding
|
DVL2 |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | up-regulates activity
binding
|
AXIN1 |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17529994 |
Dishevelled (dvl) transduces the wnt signal by interacting with the cytoplasmic axin complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DACT1 | down-regulates
binding
|
DVL2 |
0.789 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16446366 |
Dapper 1 antagonizes wnt signaling by promoting dishevelled degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BAMBI | up-regulates
binding
|
DVL2 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23037 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2662247 |
Bmp-2 mediates phosphorylated smad1 (psmad1) or, with loss of bmprii, psmad3-dependent recruitment of disheveled (dvl) to promote rhoa-rac1 signaling necessary for motility. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRP1B | down-regulates activity
binding
|
DVL2 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28408316 |
In this study, we have shown that LRP1B inhibited the activity of beta-catenin/TCF signaling possibly by interacting with DVL2. The molecular mechanism study revealed that LRP1B interacted with DVL2, inhibited the interaction between DVL2 and Axin, and negatively regulated beta-catenin/TCF signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | up-regulates activity
binding
|
DVL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17529994 |
Dix domain of dvl2 mediates dynamic polymerization, which is essential for the signaling activity of dvl2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHLRC1 | down-regulates quantity by destabilization
polyubiquitination
|
DVL2 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272005 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22223637 |
We have also found that malin enhances K48- and K63-linked ubiquitination of dishevelled2 that could lead to its degradation through both proteasome and autophagy. Altogether, our results indicate that malin regulates Wnt signaling pathway through the degradation of dishevelled2 and suggest possible deregulation of Wnt signaling in Lafora disease. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD4 | up-regulates activity
binding
|
DVL2 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12958364 |
Endocytosis of frizzled 4 (fz4) in human embryonic kidney 293 cells was dependent on added wnt5a protein and was accomplished by the multifunctional adaptor protein beta-arrestin 2 (betaarr2), which was recruited to fz4 by binding to phosphorylated dvl2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27096005 |
Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SDC4 | up-regulates
binding
|
DVL2 |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Like other wnt co receptors, syndecan 4 directly interacts with dvl during pcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | down-regulates activity
binding
|
RBPJ |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243999 |
|
|
Cricetulus griseus |
CHO-K1 Cell |
| pmid |
sentence |
| 23132247 |
Mechanistically, Dishevelled binds and directly inhibits CSL transcription factors downstream of Notch receptors, reducing their activity. Furthermore, our data suggest that this crosstalk mechanism is conserved between vertebrate and invertebrate homologues. Thus, we identify a dual function for Dishevelled as an inhibitor of Notch signalling and an activator of the Wnt pathway that sharpens the distinction between opposing Wnt and Notch responses, allowing for robust cell-fate decisions. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
FZD5 | up-regulates activity
binding
|
DVL2 |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258960 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNF185 | down-regulates quantity by destabilization
polyubiquitination
|
DVL2 |
0.469 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272173 |
|
|
Mus musculus |
MC3T3-E1 Cell |
| pmid |
sentence |
| 24727453 |
The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation. Overexpression of RNF185 decreases the exogenous and endogenous level of Dvl2, promotes the ubiquitination and degradation of Dvl2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ANKRD6 | up-regulates
binding
|
DVL2 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162142 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20006983 |
Our data thus demonstrate that diversin and dishevelled function together in a mutually dependent fashion in zebrafish gastrulation and organ formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1E | up-regulates activity
phosphorylation
|
DVL2 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244097 |
|
|
Caenorhabditis elegans |
|
| pmid |
sentence |
| 10517632 |
In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway |
|
| Publications: |
1 |
Organism: |
Caenorhabditis Elegans |
| + |
DVL2 | up-regulates activity
|
PLCB1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258979 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19279717 |
Dsh through PLC activates IP3, which leads to release of intracellular Ca2+, which in turn activates CamK11 and calcineurin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RYK | up-regulates
binding
|
DVL2 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15454084 |
Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | up-regulates
binding
|
PARD6A |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
In pcp , dvl binds to proteins such as pkc, atypical pkc (apkc), dvl-associated activator of morphogenesis 1 (daam1), dvl-associating protein with a high frequency of leu residues (daple) and partitioning defective 6 (par6), which are important for the regulation of small gtpases such as rho and rac and, consequently, the cytoskeleton and cell polarity58. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TM4SF1 | up-regulates activity
binding
|
DVL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272402 |
|
|
|
|
| pmid |
sentence |
| 33015133 |
TM4SF1 is a partner of DVL2 and positively modulates Wnt/beta-catenin signaling by enhancing DVL2-Axin interaction. |
|
| Publications: |
1 |
| + |
FZD1 | up-regulates activity
binding
|
DVL2 |
0.681 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DVL2 | up-regulates activity
binding
|
LRP6 |
0.695 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-66362 |
|
|
Homo sapiens |
L-929 Cell |
| pmid |
sentence |
| 10196136 |
Dvl is required for lrp6 phosphorylation, which is essential for subsequent steps of signal transduction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
DVL2
- 
- 