Summary

Name DVL2
Full Name Segment polarity protein dishevelled homolog DVL-2
Synonyms Dishevelled-2, DSH homolog 2
Primary ID O14641
Links - -
Type protein
Relations 28
Function Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.691
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.532
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation DVL2 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.468
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PARD6A 0.641
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AXIN1 0.666
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.702
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GSK3B/Axin/APC 0.651
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png binding DVL2 0.79
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.258
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding DVL2 0.387
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.512
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png PLCB1 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.75
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL2 0.691
Publications: 1 Organism: Caenorhabditis Elegans
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DVL2 0.469
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding DVL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.689
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.649
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DVL2 0.465
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.677
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RBPJ 0.269
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png binding DVL2 0.477
Publications: 1 Organism: Homo Sapiens