Summary

Name DVL2
Full Name Segment polarity protein dishevelled homolog DVL-2
Synonyms Dishevelled-2, DSH homolog 2
Primary ID O14641
Links - -
Type protein
Relations 28
Function Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.685
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation DVL2 0.322
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.525
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.473
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RBPJ 0.271
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png binding GSK3B/Axin/APC 0.644
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.482
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding DVL2 0.786
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.426
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding DVL2 0.391
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PARD6A 0.634
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DVL2 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DVL2 0.505
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png binding DVL2 0.745
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL2 0.685
Publications: 1 Organism: Caenorhabditis Elegans
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination DVL2 0.474
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding DVL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.642
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.683
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AXIN1 0.66
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.697
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png PLCB1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL2 0.67
Publications: 1 Organism: Homo Sapiens