| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | DVL2 | Ser143 | FHPNVSSsHENLEPE | phosphorylation up-regulates | 22609948 | SIGNOR-197063 |
| CSNK1D | DVL2 | Ser143 | FHPNVSSsHENLEPE | phosphorylation up-regulates | 22609948 | SIGNOR-197547 |
| PTEN | DVL2 | Ser143 | FHPNVSSsHENLEPE | dephosphorylation down-regulates activity | 26399523 | SIGNOR-277035 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | phosphorylation up-regulates → | DVL2 PSer143 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197063 |
| CSNK1D | phosphorylation up-regulates → | DVL2 PSer143 | phosphorylation up-regulates → | DVL2 | 22609948 | SIGNOR-197547 |
| PTEN | dephosphorylation down-regulates ⊣ | DVL2 PSer143 | dephosphorylation up-regulates → | DVL2 | 26399523 | SIGNOR-277035 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1E | phosphorylation → up-regulates | DVL2 | SIGNOR-197063 |
| CSNK1D | phosphorylation → up-regulates | DVL2 | SIGNOR-197547 |
| PTEN | dephosphorylation → down-regulates activity | DVL2 | SIGNOR-277035 |
