| Name | AURKA |
| ID | O14965 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 133-383 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | TP73 | Ser235 | DPVTGRQsVVVPYEP | phosphorylation down-regulates activity | 22340593 | SIGNOR-278263 |
| AURKA | TP53 | Ser215 | DRNTFRHsVVVPYEP | phosphorylation down-regulates | 15469940 | SIGNOR-129809 |
| AURKA | RASSF1 | Thr206 | GTSVRRRtSFYLPKD | phosphorylation down-regulates | 17563743 | SIGNOR-155819 |
| AURKA | PARD3 | Ser962 | SSRSGREsVSTASDQ | phosphorylation up-regulates | 19812038 | SIGNOR-188398 |
| AURKA | CBX3 | – | phosphorylation up-regulates activity | 23829974 | SIGNOR-280185 | |
| AURKA | CCNB1 | – | phosphorylation up-regulates activity | 30250494 | SIGNOR-280186 | |
| AURKA | CENPE | – | phosphorylation down-regulates activity | 31881080 | SIGNOR-280187 | |
| AURKA | PTK2 | – | phosphorylation up-regulates activity | 25501815 | SIGNOR-280188 | |
| AURKA | BCL2L11 | Ser94 | SLLSRSSsGYFSFDT | phosphorylation down-regulates quantity by destabilization | 23912711 | SIGNOR-276248 |
| AURKA | POU6F1 | Ser197 | KLDITPKsAQKLKPV | phosphorylation down-regulates activity | 31665313 | SIGNOR-273546 |
| AURKA | KNSTRN | – | phosphorylation down-regulates activity | 22535524 | SIGNOR-252052 | |
| AURKA | SPAG5 | Ser115 | ISSTPKTsEEAVDPL | phosphorylation up-regulates activity | 25009111 | SIGNOR-276648 |
| AURKA | ALDH1A1 | Thr493 | YTEVKTVtVKISQKN | phosphorylation up-regulates activity | 28193222 | SIGNOR-276749 |
| AURKA | CDC25B | Ser353 | VQNKRRRsVTPPEEQ | phosphorylation up-regulates | 16082213 | SIGNOR-139396 |
| AURKA | MCRS1 | Ser36 | AGQKRASsQALGTIP | phosphorylation up-regulates activity | 27192185 | SIGNOR-278232 |
| AURKA | ALDH1A1 | Thr493 | YTEVKTVtVKISQKN | phosphorylation up-regulates quantity | 28193222 | SIGNOR-278165 |
| AURKA | Histone H3 | – | phosphorylation unknown | 12234980 | SIGNOR-265356 | |
| AURKA | DLGAP5 | Ser757 | EGMELNSsITSQDVL | phosphorylation up-regulates quantity by stabilization | 15987997 | SIGNOR-262651 |
| AURKA | BCL2L11 | Ser98 | RSSSGYFsFDTDRSP | phosphorylation down-regulates quantity by destabilization | 23912711 | SIGNOR-276246 |
| AURKA | FADD | Ser203 | MSWNSDAsTSEAS | phosphorylation up-regulates | 21978935 | SIGNOR-176739 |
| AURKA | MAP9 | Ser625 | RKQKKRHsFLESEAL | phosphorylation up-regulates | 17925329 | SIGNOR-158210 |
| AURKA | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 24173284 | SIGNOR-120836 |
| AURKA | INCENP | – | phosphorylation up-regulates activity | 16824953 | SIGNOR-252047 | |
| AURKA | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates activity | 23993973 | SIGNOR-278912 |
| AURKA | DLGAP5 | Ser725 | CLSSERMsLPLLAGG | phosphorylation up-regulates quantity by stabilization | 15987997 | SIGNOR-262650 |
| AURKA | WDR62 | Ser32 | VPARRGQsSPPPAPP | phosphorylation up-regulates activity | 25501809 | SIGNOR-271712 |
| AURKA | SECISBP2L | Thr573 | IAKLKRPtALKKVIL | phosphorylation up-regulates quantity | 31314582 | SIGNOR-273547 |
| AURKA | ARPC1B | Thr21 | HAWNKDRtQIAICPN | phosphorylation up-regulates activity | 20603326 | SIGNOR-279438 |
| AURKA | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates activity | 24166501 | SIGNOR-278507 |
| AURKA | ESR1 | Ser167 | GGRERLAsTNDKGSM | phosphorylation up-regulates activity | 24166501 | SIGNOR-278508 |
| AURKA | SKI | Ser383 | LSAFRPWsPAVSASE | phosphorylation down-regulates quantity by destabilization | 26138431 | SIGNOR-276917 |
| AURKA | SOX8 | – | phosphorylation up-regulates activity | 32550913 | SIGNOR-280189 | |
| AURKA | TACC3 | Ser558 | ESALRKQsLYLKFDP | phosphorylation up-regulates activity | 17545617 | SIGNOR-262655 |
| AURKA | EIF4E | – | phosphorylation up-regulates activity | 28073841 | SIGNOR-279495 | |
| AURKA | ALDH1A1 | Thr442 | KDIDKAItISSALQA | phosphorylation up-regulates activity | 28193222 | SIGNOR-276748 |
| AURKA | KIF2C | Ser719 | EQASRQIsSKKRPQ | phosphorylation down-regulates activity | 18434591 | SIGNOR-279139 |
| AURKA | MBD3 | Ser85 | RQRVRYDsSNQVKGK | phosphorylation up-regulates | 12354758 | SIGNOR-93697 |
| AURKA | SPIN1 | Ser109 | LNKDERVsALEVLPD | phosphorylation up-regulates activity | 22258766 | SIGNOR-273549 |
| AURKA | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates quantity | 25217103 | SIGNOR-278469 |
| AURKA | ARHGEF2 | Ser960 | SRLSPPHsPRDFTRM | phosphorylation down-regulates activity | 17488622 | SIGNOR-276061 |
| AURKA | ALDH1A1 | Thr267 | KSNLKRVtLELGGKS | phosphorylation up-regulates activity | 28193222 | SIGNOR-276750 |
| AURKA | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates | 18615013 | SIGNOR-179422 |
| AURKA | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 12588998 | SIGNOR-98289 |
| AURKA | TPX2 | Ser125 | QRRSLRLsAQKDLEQ | phosphorylation up-regulates activity | 26240182 | SIGNOR-265088 |
| AURKA | FAF1 | Ser289 | ITDVHMVsDSDGDDF | phosphorylation down-regulates activity | 18790738 | SIGNOR-180887 |
| AURKA | LIMK1 | – | phosphorylation up-regulates activity | 25090971 | SIGNOR-279799 | |
| AURKA | DLGAP5 | Ser627 | VKLFSGLsVSSEGPS | phosphorylation up-regulates quantity by stabilization | 15987997 | SIGNOR-262649 |
| AURKA | DLGAP5 | Ser830 | QEHARHIsFGGNLIT | phosphorylation up-regulates quantity by stabilization | 15987997 | SIGNOR-262652 |
| AURKA | ALDH1A1 | Thr267 | KSNLKRVtLELGGKS | phosphorylation up-regulates quantity | 28193222 | SIGNOR-278166 |
| AURKA | ALDH1A1 | Thr442 | KDIDKAItISSALQA | phosphorylation up-regulates quantity | 28193222 | SIGNOR-278167 |
| AURKA | TACC3 | Ser34 | PEVTGRSsVLRVSQK | phosphorylation unknown | 26134678 | SIGNOR-263697 |
| AURKA | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 17563743 | SIGNOR-155815 |
| AURKA | MBD3 | Ser24 | REEVPRRsGLSAGHR | phosphorylation up-regulates | 12354758 | SIGNOR-93693 |
| AURKA | GSK3B | Ser9 | SGRPRTTsFAESCKP | phosphorylation down-regulates activity | 19060929 | SIGNOR-279357 |
| AURKA | CEP192 | – | phosphorylation up-regulates activity | 25042804 | SIGNOR-279797 | |
| AURKA | VHL | – | phosphorylation down-regulates quantity by destabilization | 28114281 | SIGNOR-279800 | |
| AURKA | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates quantity | 25217103 | SIGNOR-278468 |
| AURKA | CFL1 | – | phosphorylation down-regulates activity | 27003257 | SIGNOR-279798 | |
| AURKA | TP53 | Ser106 | SQKTYQGsYGFRLGF | phosphorylation up-regulates | 23201157 | SIGNOR-199939 |
| AURKA | STMN1 | – | phosphorylation down-regulates activity | 33037191 | SIGNOR-278913 | |
| AURKA | LATS2 | Ser83 | ALREIRYsLLPFANE | phosphorylation up-regulates | 15147269 | SIGNOR-124830 |
| AURKA | TIFA | Thr9 | TSFEDADtEETVTCL | phosphorylation up-regulates activity | 28069801 | SIGNOR-273551 |
| AURKA | PHLDA1 | Ser95 | PLCLLRVsLLCALRA | phosphorylation down-regulates quantity by destabilization | 21807936 | SIGNOR-273545 |
| AURKA | MAPRE3 | Ser176 | MQTSGRLsNVAPPCI | phosphorylation up-regulates | 19696028 | SIGNOR-187657 |
| AURKA | AURKA | Thr288 | APSSRRTtLCGTLDY | phosphorylation up-regulates | 24867643 | SIGNOR-205106 |
| AURKA | WDR62 | Ser33 | PARRGQSsPPPAPPI | phosphorylation up-regulates activity | 25501809 | SIGNOR-271713 |
| AURKA | SGO1 | – | phosphorylation up-regulates activity | 16824953 | SIGNOR-252046 | |
| AURKA | SPIN1 | Ser124 | RVATSRIsDAHLADT | phosphorylation up-regulates activity | 22258766 | SIGNOR-273550 |
| AURKA | NEDD1 | Ser405 | FDDTGKSsLGDMFSP | phosphorylation up-regulates activity | 31028180 | SIGNOR-272965 |
| AURKA | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12234980 | SIGNOR-118886 |
| AURKA | AURKAIP1 | Ser70 | MLVPRKMsVSPLESW | phosphorylation up-regulates quantity by stabilization | 17957726 | SIGNOR-262648 |
| AURKA | RALA | Ser194 | NGKKKRKsLAKRIRE | phosphorylation up-regulates activity | 21822277 | SIGNOR-278351 |
| AURKA | BRCA1 | Ser308 | KAEFCNKsKQPGLAR | phosphorylation up-regulates | 14990569 | SIGNOR-123065 |
| AURKA | GMNN | Thr25 | NSSVPRRtLKMIQPS | phosphorylation up-regulates activity | 23695679 | SIGNOR-278509 |
| AURKA | LDHB | Ser162 | PKHRVIGsGCNLDSA | phosphorylation up-regulates activity | 31804482 | SIGNOR-277493 |
| AURKA | FANCA | Ser165 | HSMFSRLsFCQELWK | phosphorylation up-regulates activity | 27398318 | SIGNOR-277263 |
| AURKA | LIMK1 | Ser307 | DRSPGAGsLGSPASQ | phosphorylation up-regulates activity | 22214762 | SIGNOR-276399 |
| AURKA | KIF4A | Thr799 | PPKLRRRtFSLTEVR | phosphorylation up-regulates activity | 31881080 | SIGNOR-265993 |
| AURKA | EGFR | Thr678 | RHIVRKRtLRRLLQE | phosphorylation up-regulates activity | 23520446 | SIGNOR-279590 |
| AURKA | TACC3 | Ser552 | GTSSFKEsALRKQSL | phosphorylation unknown | 26134678 | SIGNOR-263698 |
| AURKA | NSD2 | Ser56 | SKAQLSSsLQEGVMQ | phosphorylation up-regulates quantity by stabilization | 35389552 | SIGNOR-275512 |
| AURKA | SOX8 | Ser327 | SAPSASAsPTETGPP | phosphorylation up-regulates activity | 32550913 | SIGNOR-273548 |
| AURKA | CETN2 | Ser170 | LRIMKKTsLY | phosphorylation up-regulates | 21731694 | SIGNOR-174686 |
| AURKA | PIN1 | Ser16 | PGWEKRMsRSSGRVY | phosphorylation down-regulates activity | 23970419 | SIGNOR-202487 |
| AURKA | SKI | Ser326 | RRVPRVSsEPPASIR | phosphorylation down-regulates quantity by destabilization | 26138431 | SIGNOR-276918 |
| AURKA | EGFR | Ser1070 | DSFLQRYsSDPTGAL | phosphorylation up-regulates activity | 23520446 | SIGNOR-279589 |
| AURKA | GSK3B/Axin/APC | – | phosphorylation down-regulates activity | 19060929 | SIGNOR-227923 | |
| AURKA | KCTD12 | Ser243 | ITVCGKTsLAKEVFG | phosphorylation up-regulates activity | 28869606 | SIGNOR-273544 |
| AURKA | NDEL1 | Ser251 | LTPSARIsALNIVGD | phosphorylation down-regulates quantity by destabilization | 17060449 | SIGNOR-263159 |
| AURKA | BCL2L11 | Ser93 | SSLLSRSsSGYFSFD | phosphorylation down-regulates quantity by destabilization | 23912711 | SIGNOR-276247 |
| AURKA | FAF1 | Ser291 | DVHMVSDsDGDDFED | phosphorylation down-regulates activity | 18790738 | SIGNOR-180891 |
| AURKA | LATS2 | Ser380 | ATLARRDsLQKPGLE | phosphorylation up-regulates | 21822051 | SIGNOR-175939 |
| AURKA | WWC1 | Ser539 | TSLSPRSsLSSPSPP | phosphorylation unknown | 21878642 | SIGNOR-176359 |
| AURKA | BCL2L11 | – | phosphorylation down-regulates quantity | 23912711 | SIGNOR-279009 | |
| AURKA | NEDD9 | Ser296 | PVARRHQsLSPNHPP | phosphorylation up-regulates activity | 16184168 | SIGNOR-262654 |
| AURKA | TPX2 | Ser121 | PAQPQRRsLRLSAQK | phosphorylation up-regulates activity | 26240182 | SIGNOR-265089 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | TP73 PSer235 | phosphorylation down-regulates ⊣ | TP73 | 22340593 | SIGNOR-278263 |
| AURKA | phosphorylation up-regulates → | TP53 PSer215 | phosphorylation down-regulates ⊣ | TP53 | 15469940 | SIGNOR-129809 |
| AURKA | phosphorylation up-regulates → | RASSF1 PThr206 | phosphorylation down-regulates ⊣ | RASSF1 | 17563743 | SIGNOR-155819 |
| AURKA | phosphorylation up-regulates → | PARD3 PSer962 | phosphorylation up-regulates → | PARD3 | 19812038 | SIGNOR-188398 |
| AURKA | phosphorylation up-regulates → | BCL2L11 PSer94 | phosphorylation down-regulates ⊣ | BCL2L11 | 23912711 | SIGNOR-276248 |
| AURKA | phosphorylation up-regulates → | POU6F1 PSer197 | phosphorylation down-regulates ⊣ | POU6F1 | 31665313 | SIGNOR-273546 |
| AURKA | phosphorylation up-regulates → | SPAG5 PSer115 | phosphorylation up-regulates → | SPAG5 | 25009111 | SIGNOR-276648 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr493 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-276749 |
| AURKA | phosphorylation up-regulates → | CDC25B PSer353 | phosphorylation up-regulates → | CDC25B | 16082213 | SIGNOR-139396 |
| AURKA | phosphorylation up-regulates → | MCRS1 PSer36 | phosphorylation up-regulates → | MCRS1 | 27192185 | SIGNOR-278232 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr493 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-278165 |
| AURKA | phosphorylation up-regulates → | DLGAP5 PSer757 | phosphorylation up-regulates → | DLGAP5 | 15987997 | SIGNOR-262651 |
| AURKA | phosphorylation up-regulates → | BCL2L11 PSer98 | phosphorylation down-regulates ⊣ | BCL2L11 | 23912711 | SIGNOR-276246 |
| AURKA | phosphorylation up-regulates → | FADD PSer203 | phosphorylation up-regulates → | FADD | 21978935 | SIGNOR-176739 |
| AURKA | phosphorylation up-regulates → | MAP9 PSer625 | phosphorylation up-regulates → | MAP9 | 17925329 | SIGNOR-158210 |
| AURKA | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 24173284 | SIGNOR-120836 |
| AURKA | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 23993973 | SIGNOR-278912 |
| AURKA | phosphorylation up-regulates → | DLGAP5 PSer725 | phosphorylation up-regulates → | DLGAP5 | 15987997 | SIGNOR-262650 |
| AURKA | phosphorylation up-regulates → | WDR62 PSer32 | phosphorylation up-regulates → | WDR62 | 25501809 | SIGNOR-271712 |
| AURKA | phosphorylation up-regulates → | SECISBP2L PThr573 | phosphorylation up-regulates → | SECISBP2L | 31314582 | SIGNOR-273547 |
| AURKA | phosphorylation up-regulates → | ARPC1B PThr21 | phosphorylation up-regulates → | ARPC1B | 20603326 | SIGNOR-279438 |
| AURKA | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 24166501 | SIGNOR-278507 |
| AURKA | phosphorylation up-regulates → | ESR1 PSer167 | phosphorylation up-regulates → | ESR1 | 24166501 | SIGNOR-278508 |
| AURKA | phosphorylation up-regulates → | SKI PSer383 | phosphorylation down-regulates ⊣ | SKI | 26138431 | SIGNOR-276917 |
| AURKA | phosphorylation up-regulates → | TACC3 PSer558 | phosphorylation up-regulates → | TACC3 | 17545617 | SIGNOR-262655 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr442 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-276748 |
| AURKA | phosphorylation up-regulates → | KIF2C PSer719 | phosphorylation down-regulates ⊣ | KIF2C | 18434591 | SIGNOR-279139 |
| AURKA | phosphorylation up-regulates → | MBD3 PSer85 | phosphorylation up-regulates → | MBD3 | 12354758 | SIGNOR-93697 |
| AURKA | phosphorylation up-regulates → | SPIN1 PSer109 | phosphorylation up-regulates → | SPIN1 | 22258766 | SIGNOR-273549 |
| AURKA | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 25217103 | SIGNOR-278469 |
| AURKA | phosphorylation up-regulates → | ARHGEF2 PSer960 | phosphorylation down-regulates ⊣ | ARHGEF2 | 17488622 | SIGNOR-276061 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr267 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-276750 |
| AURKA | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 18615013 | SIGNOR-179422 |
| AURKA | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation up-regulates → | H3C1 | 12588998 | SIGNOR-98289 |
| AURKA | phosphorylation up-regulates → | TPX2 PSer125 | phosphorylation up-regulates → | TPX2 | 26240182 | SIGNOR-265088 |
| AURKA | phosphorylation up-regulates → | FAF1 PSer289 | phosphorylation down-regulates ⊣ | FAF1 | 18790738 | SIGNOR-180887 |
| AURKA | phosphorylation up-regulates → | DLGAP5 PSer627 | phosphorylation up-regulates → | DLGAP5 | 15987997 | SIGNOR-262649 |
| AURKA | phosphorylation up-regulates → | DLGAP5 PSer830 | phosphorylation up-regulates → | DLGAP5 | 15987997 | SIGNOR-262652 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr267 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-278166 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr442 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-278167 |
| AURKA | phosphorylation up-regulates → | TACC3 PSer34 | phosphorylation down-regulates ⊣ | TACC3 | 26134678 | SIGNOR-263697 |
| AURKA | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 17563743 | SIGNOR-155815 |
| AURKA | phosphorylation up-regulates → | MBD3 PSer24 | phosphorylation up-regulates → | MBD3 | 12354758 | SIGNOR-93693 |
| AURKA | phosphorylation up-regulates → | GSK3B PSer9 | phosphorylation down-regulates ⊣ | GSK3B | 19060929 | SIGNOR-279357 |
| AURKA | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 25217103 | SIGNOR-278468 |
| AURKA | phosphorylation up-regulates → | TP53 PSer106 | phosphorylation up-regulates → | TP53 | 23201157 | SIGNOR-199939 |
| AURKA | phosphorylation up-regulates → | LATS2 PSer83 | phosphorylation up-regulates → | LATS2 | 15147269 | SIGNOR-124830 |
| AURKA | phosphorylation up-regulates → | TIFA PThr9 | phosphorylation up-regulates → | TIFA | 28069801 | SIGNOR-273551 |
| AURKA | phosphorylation up-regulates → | PHLDA1 PSer95 | phosphorylation down-regulates ⊣ | PHLDA1 | 21807936 | SIGNOR-273545 |
| AURKA | phosphorylation up-regulates → | MAPRE3 PSer176 | phosphorylation up-regulates → | MAPRE3 | 19696028 | SIGNOR-187657 |
| AURKA | phosphorylation up-regulates → | AURKA PThr288 | phosphorylation up-regulates → | AURKA | 24867643 | SIGNOR-205106 |
| AURKA | phosphorylation up-regulates → | WDR62 PSer33 | phosphorylation up-regulates → | WDR62 | 25501809 | SIGNOR-271713 |
| AURKA | phosphorylation up-regulates → | SPIN1 PSer124 | phosphorylation up-regulates → | SPIN1 | 22258766 | SIGNOR-273550 |
| AURKA | phosphorylation up-regulates → | NEDD1 PSer405 | phosphorylation up-regulates → | NEDD1 | 31028180 | SIGNOR-272965 |
| AURKA | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 12234980 | SIGNOR-118886 |
| AURKA | phosphorylation up-regulates → | AURKAIP1 PSer70 | phosphorylation up-regulates → | AURKAIP1 | 17957726 | SIGNOR-262648 |
| AURKA | phosphorylation up-regulates → | RALA PSer194 | phosphorylation up-regulates → | RALA | 21822277 | SIGNOR-278351 |
| AURKA | phosphorylation up-regulates → | BRCA1 PSer308 | phosphorylation up-regulates → | BRCA1 | 14990569 | SIGNOR-123065 |
| AURKA | phosphorylation up-regulates → | GMNN PThr25 | phosphorylation up-regulates → | GMNN | 23695679 | SIGNOR-278509 |
| AURKA | phosphorylation up-regulates → | LDHB PSer162 | phosphorylation up-regulates → | LDHB | 31804482 | SIGNOR-277493 |
| AURKA | phosphorylation up-regulates → | FANCA PSer165 | phosphorylation up-regulates → | FANCA | 27398318 | SIGNOR-277263 |
| AURKA | phosphorylation up-regulates → | LIMK1 PSer307 | phosphorylation up-regulates → | LIMK1 | 22214762 | SIGNOR-276399 |
| AURKA | phosphorylation up-regulates → | KIF4A PThr799 | phosphorylation up-regulates → | KIF4A | 31881080 | SIGNOR-265993 |
| AURKA | phosphorylation up-regulates → | EGFR PThr678 | phosphorylation up-regulates → | EGFR | 23520446 | SIGNOR-279590 |
| AURKA | phosphorylation up-regulates → | TACC3 PSer552 | phosphorylation down-regulates ⊣ | TACC3 | 26134678 | SIGNOR-263698 |
| AURKA | phosphorylation up-regulates → | NSD2 PSer56 | phosphorylation up-regulates → | NSD2 | 35389552 | SIGNOR-275512 |
| AURKA | phosphorylation up-regulates → | SOX8 PSer327 | phosphorylation up-regulates → | SOX8 | 32550913 | SIGNOR-273548 |
| AURKA | phosphorylation up-regulates → | CETN2 PSer170 | phosphorylation up-regulates → | CETN2 | 21731694 | SIGNOR-174686 |
| AURKA | phosphorylation up-regulates → | PIN1 PSer16 | phosphorylation down-regulates ⊣ | PIN1 | 23970419 | SIGNOR-202487 |
| AURKA | phosphorylation up-regulates → | SKI PSer326 | phosphorylation down-regulates ⊣ | SKI | 26138431 | SIGNOR-276918 |
| AURKA | phosphorylation up-regulates → | EGFR PSer1070 | phosphorylation up-regulates → | EGFR | 23520446 | SIGNOR-279589 |
| AURKA | phosphorylation up-regulates → | KCTD12 PSer243 | phosphorylation up-regulates → | KCTD12 | 28869606 | SIGNOR-273544 |
| AURKA | phosphorylation up-regulates → | NDEL1 PSer251 | phosphorylation down-regulates ⊣ | NDEL1 | 17060449 | SIGNOR-263159 |
| AURKA | phosphorylation up-regulates → | BCL2L11 PSer93 | phosphorylation down-regulates ⊣ | BCL2L11 | 23912711 | SIGNOR-276247 |
| AURKA | phosphorylation up-regulates → | FAF1 PSer291 | phosphorylation down-regulates ⊣ | FAF1 | 18790738 | SIGNOR-180891 |
| AURKA | phosphorylation up-regulates → | LATS2 PSer380 | phosphorylation up-regulates → | LATS2 | 21822051 | SIGNOR-175939 |
| AURKA | phosphorylation up-regulates → | WWC1 PSer539 | phosphorylation down-regulates ⊣ | WWC1 | 21878642 | SIGNOR-176359 |
| AURKA | phosphorylation up-regulates → | NEDD9 PSer296 | phosphorylation up-regulates → | NEDD9 | 16184168 | SIGNOR-262654 |
| AURKA | phosphorylation up-regulates → | TPX2 PSer121 | phosphorylation up-regulates → | TPX2 | 26240182 | SIGNOR-265089 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation → down-regulates activity | TP73 | SIGNOR-278263 |
| AURKA | phosphorylation down-regulates | TP53 | SIGNOR-129809 |
| AURKA | phosphorylation down-regulates | RASSF1 | SIGNOR-155819 |
| AURKA | phosphorylation → up-regulates | PARD3 | SIGNOR-188398 |
| AURKA | phosphorylation → up-regulates activity | CBX3 | SIGNOR-280185 |
| AURKA | phosphorylation → up-regulates activity | CCNB1 | SIGNOR-280186 |
| AURKA | phosphorylation → down-regulates activity | CENPE | SIGNOR-280187 |
| AURKA | phosphorylation → up-regulates activity | PTK2 | SIGNOR-280188 |
| AURKA | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-276248 |
| AURKA | phosphorylation → down-regulates activity | POU6F1 | SIGNOR-273546 |
| AURKA | phosphorylation → down-regulates activity | KNSTRN | SIGNOR-252052 |
| AURKA | phosphorylation → up-regulates activity | SPAG5 | SIGNOR-276648 |
| AURKA | phosphorylation → up-regulates activity | ALDH1A1 | SIGNOR-276749 |
| AURKA | phosphorylation → up-regulates | CDC25B | SIGNOR-139396 |
| AURKA | phosphorylation → up-regulates activity | MCRS1 | SIGNOR-278232 |
| AURKA | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-278165 |
| AURKA | phosphorylation → unknown | Histone H3 | SIGNOR-265356 |
| AURKA | phosphorylation → up-regulates quantity by stabilization | DLGAP5 | SIGNOR-262651 |
| AURKA | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-276246 |
| AURKA | phosphorylation → up-regulates | FADD | SIGNOR-176739 |
| AURKA | phosphorylation → up-regulates | MAP9 | SIGNOR-158210 |
| AURKA | phosphorylation → up-regulates activity | TP53 | SIGNOR-120836 |
| AURKA | phosphorylation → up-regulates activity | INCENP | SIGNOR-252047 |
| AURKA | phosphorylation → down-regulates activity | NFKBIA | SIGNOR-278912 |
| AURKA | phosphorylation → up-regulates quantity by stabilization | DLGAP5 | SIGNOR-262650 |
| AURKA | phosphorylation → up-regulates activity | WDR62 | SIGNOR-271712 |
| AURKA | phosphorylation → up-regulates quantity | SECISBP2L | SIGNOR-273547 |
| AURKA | phosphorylation → up-regulates activity | ARPC1B | SIGNOR-279438 |
| AURKA | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278507 |
| AURKA | phosphorylation → up-regulates activity | ESR1 | SIGNOR-278508 |
| AURKA | phosphorylation down-regulates quantity by destabilization | SKI | SIGNOR-276917 |
| AURKA | phosphorylation → up-regulates activity | SOX8 | SIGNOR-280189 |
| AURKA | phosphorylation → up-regulates activity | TACC3 | SIGNOR-262655 |
| AURKA | phosphorylation → up-regulates activity | EIF4E | SIGNOR-279495 |
| AURKA | phosphorylation → up-regulates activity | ALDH1A1 | SIGNOR-276748 |
| AURKA | phosphorylation → down-regulates activity | KIF2C | SIGNOR-279139 |
| AURKA | phosphorylation → up-regulates | MBD3 | SIGNOR-93697 |
| AURKA | phosphorylation → up-regulates activity | SPIN1 | SIGNOR-273549 |
| AURKA | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-278469 |
| AURKA | phosphorylation → down-regulates activity | ARHGEF2 | SIGNOR-276061 |
| AURKA | phosphorylation → up-regulates activity | ALDH1A1 | SIGNOR-276750 |
| AURKA | phosphorylation → up-regulates | PLK1 | SIGNOR-179422 |
| AURKA | phosphorylation → up-regulates activity | H3C1 | SIGNOR-98289 |
| AURKA | phosphorylation → up-regulates activity | TPX2 | SIGNOR-265088 |
| AURKA | phosphorylation → down-regulates activity | FAF1 | SIGNOR-180887 |
| AURKA | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-279799 |
| AURKA | phosphorylation → up-regulates quantity by stabilization | DLGAP5 | SIGNOR-262649 |
| AURKA | phosphorylation → up-regulates quantity by stabilization | DLGAP5 | SIGNOR-262652 |
| AURKA | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-278166 |
| AURKA | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-278167 |
| AURKA | phosphorylation → unknown | TACC3 | SIGNOR-263697 |
| AURKA | phosphorylation down-regulates | RASSF1 | SIGNOR-155815 |
| AURKA | phosphorylation → up-regulates | MBD3 | SIGNOR-93693 |
| AURKA | phosphorylation → down-regulates activity | GSK3B | SIGNOR-279357 |
| AURKA | phosphorylation → up-regulates activity | CEP192 | SIGNOR-279797 |
| AURKA | phosphorylation down-regulates quantity by destabilization | VHL | SIGNOR-279800 |
| AURKA | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-278468 |
| AURKA | phosphorylation → down-regulates activity | CFL1 | SIGNOR-279798 |
| AURKA | phosphorylation → up-regulates | TP53 | SIGNOR-199939 |
| AURKA | phosphorylation → down-regulates activity | STMN1 | SIGNOR-278913 |
| AURKA | phosphorylation → up-regulates | LATS2 | SIGNOR-124830 |
| AURKA | phosphorylation → up-regulates activity | TIFA | SIGNOR-273551 |
| AURKA | phosphorylation down-regulates quantity by destabilization | PHLDA1 | SIGNOR-273545 |
| AURKA | phosphorylation → up-regulates | MAPRE3 | SIGNOR-187657 |
| AURKA | phosphorylation → up-regulates | AURKA | SIGNOR-205106 |
| AURKA | phosphorylation → up-regulates activity | WDR62 | SIGNOR-271713 |
| AURKA | phosphorylation → up-regulates activity | SGO1 | SIGNOR-252046 |
| AURKA | phosphorylation → up-regulates activity | SPIN1 | SIGNOR-273550 |
| AURKA | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272965 |
| AURKA | phosphorylation → unknown | H3C1 | SIGNOR-118886 |
| AURKA | phosphorylation → up-regulates quantity by stabilization | AURKAIP1 | SIGNOR-262648 |
| AURKA | phosphorylation → up-regulates activity | RALA | SIGNOR-278351 |
| AURKA | phosphorylation → up-regulates | BRCA1 | SIGNOR-123065 |
| AURKA | phosphorylation → up-regulates activity | GMNN | SIGNOR-278509 |
| AURKA | phosphorylation → up-regulates activity | LDHB | SIGNOR-277493 |
| AURKA | phosphorylation → up-regulates activity | FANCA | SIGNOR-277263 |
| AURKA | phosphorylation → up-regulates activity | LIMK1 | SIGNOR-276399 |
| AURKA | phosphorylation → up-regulates activity | KIF4A | SIGNOR-265993 |
| AURKA | phosphorylation → up-regulates activity | EGFR | SIGNOR-279590 |
| AURKA | phosphorylation → unknown | TACC3 | SIGNOR-263698 |
| AURKA | phosphorylation → up-regulates quantity by stabilization | NSD2 | SIGNOR-275512 |
| AURKA | phosphorylation → up-regulates activity | SOX8 | SIGNOR-273548 |
| AURKA | phosphorylation → up-regulates | CETN2 | SIGNOR-174686 |
| AURKA | phosphorylation → down-regulates activity | PIN1 | SIGNOR-202487 |
| AURKA | phosphorylation down-regulates quantity by destabilization | SKI | SIGNOR-276918 |
| AURKA | phosphorylation → up-regulates activity | EGFR | SIGNOR-279589 |
| AURKA | phosphorylation → down-regulates activity | GSK3B/Axin/APC | SIGNOR-227923 |
| AURKA | phosphorylation → up-regulates activity | KCTD12 | SIGNOR-273544 |
| AURKA | phosphorylation down-regulates quantity by destabilization | NDEL1 | SIGNOR-263159 |
| AURKA | phosphorylation down-regulates quantity by destabilization | BCL2L11 | SIGNOR-276247 |
| AURKA | phosphorylation → down-regulates activity | FAF1 | SIGNOR-180891 |
| AURKA | phosphorylation → up-regulates | LATS2 | SIGNOR-175939 |
| AURKA | phosphorylation → unknown | WWC1 | SIGNOR-176359 |
| AURKA | phosphorylation → down-regulates quantity | BCL2L11 | SIGNOR-279009 |
| AURKA | phosphorylation → up-regulates activity | NEDD9 | SIGNOR-262654 |
| AURKA | phosphorylation → up-regulates activity | TPX2 | SIGNOR-265089 |