Summary

Name AURKA
Full Name Aurora kinase A
Synonyms Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A | AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Primary ID O14965
Links - -
Type protein
Relations 54
Inhibitors Danusertib; AMG 900; Tozasertib; 1,9-Pyrazoloanthrone; Alisertib; PF-03814735; MK-5108; PHA-680632; Aurora A Inhibitor I; SNS-314 Mesylate; AT9283; CCT129202; CCT137690; 331771-20-1; MLN8054; ENMD-2076; JNJ-7706621; CYC-116
Function Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TP53 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HIST1H3A 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PIN1 0.40
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CETN2 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPRE3 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FADD 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TP53 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AR
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MBD3 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FAF1 0.52
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC25B 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LATS2 0.31
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation WWC1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP9 0.18
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PARD3 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLK1 0.62
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AURKA 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AURKA
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AURKA
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AURKA
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation SGO1
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation INCENP
Publications: 1 Organism: Drosophila Melanogaster
+ up-regulates activity img/direct-activation.png binding AURKA
Publications: 1 Organism: Drosophila Melanogaster
+ down-regulates activity img/direct_inhibition.png phosphorylation KNSTRN
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AURKA 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GSK3B/Axin/APC
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AURKA 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA
Publications: 1 Organism: Homo Sapiens