| Name | AURKA |
| ID | O14965 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 133-383 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | AURKA | Ser283 | GWSVHAPsSRRTTLC | phosphorylation down-regulates quantity by destabilization | 38442201 | SIGNOR-277919 |
| PAK1 | AURKA | Thr288 | APSSRRTtLCGTLDY | phosphorylation up-regulates | 24867643 | SIGNOR-205110 |
| PRKACA | AURKA | Thr288 | APSSRRTtLCGTLDY | phosphorylation up-regulates activity | 11039908 | SIGNOR-250337 |
| PPP1CA | AURKA | – | dephosphorylation down-regulates | 11551964 | SIGNOR-110411 | |
| GSK3B | AURKA | – | phosphorylation down-regulates activity | 26835416 | SIGNOR-279718 | |
| PP1 | AURKA | – | dephosphorylation down-regulates | 11551964 | SIGNOR-264651 | |
| SRC | AURKA | Thr288 | APSSRRTtLCGTLDY | phosphorylation up-regulates activity | 25501815 | SIGNOR-279286 |
| LIMK1 | AURKA | – | phosphorylation up-regulates activity | 22214762 | SIGNOR-276400 | |
| AURKA | AURKA | Thr288 | APSSRRTtLCGTLDY | phosphorylation up-regulates | 24867643 | SIGNOR-205106 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | AURKA PSer283 | phosphorylation down-regulates ⊣ | AURKA | 38442201 | SIGNOR-277919 |
| PAK1 | phosphorylation up-regulates → | AURKA PThr288 | phosphorylation up-regulates → | AURKA | 24867643 | SIGNOR-205110 |
| PRKACA | phosphorylation up-regulates → | AURKA PThr288 | phosphorylation up-regulates → | AURKA | 11039908 | SIGNOR-250337 |
| SRC | phosphorylation up-regulates → | AURKA PThr288 | phosphorylation up-regulates → | AURKA | 25501815 | SIGNOR-279286 |
| AURKA | phosphorylation up-regulates → | AURKA PThr288 | phosphorylation up-regulates → | AURKA | 24867643 | SIGNOR-205106 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates quantity by destabilization | AURKA | SIGNOR-277919 |
| PAK1 | phosphorylation → up-regulates | AURKA | SIGNOR-205110 |
| PRKACA | phosphorylation → up-regulates activity | AURKA | SIGNOR-250337 |
| PPP1CA | dephosphorylation down-regulates | AURKA | SIGNOR-110411 |
| GSK3B | phosphorylation → down-regulates activity | AURKA | SIGNOR-279718 |
| PP1 | dephosphorylation down-regulates | AURKA | SIGNOR-264651 |
| SRC | phosphorylation → up-regulates activity | AURKA | SIGNOR-279286 |
| LIMK1 | phosphorylation → up-regulates activity | AURKA | SIGNOR-276400 |
| AURKA | phosphorylation → up-regulates | AURKA | SIGNOR-205106 |