| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ILK | PPP1R12A | Thr710 | DLQEAEKtIGRSRST | phosphorylation down-regulates | 12030846 | SIGNOR-87928 |
| ILK | PPP1R12A | Thr710 | DLQEAEKtIGRSRST | phosphorylation down-regulates activity | 12030846 | SIGNOR-262885 |
| LATS1 | PPP1R12A | Ser445 | LGLRKTGsYGALAEI | phosphorylation up-regulates activity | 22641346 | SIGNOR-278184 |
| NUAK1 | PPP1R12A | Ser910 | SLLGRSGsYSYLEER | phosphorylation down-regulates | 20354225 | SIGNOR-22572 |
| RAF1 | PPP1R12A | – | phosphorylation down-regulates activity | 22225925 | SIGNOR-278979 | |
| NUAK2 | PPP1R12A | – | phosphorylation down-regulates activity | 30622137 | SIGNOR-279081 | |
| ILK | PPP1R12A | Thr696 | ARQSRRStQGVTLTD | phosphorylation down-regulates activity | 12030846 | SIGNOR-262886 |
| NUAK1 | PPP1R12A | Ser472 | AGVTRSAsSPRLSSS | phosphorylation down-regulates | 20354225 | SIGNOR-164751 |
| DAPK3 | PPP1R12A | – | phosphorylation down-regulates activity | 20130087 | SIGNOR-279030 | |
| ROCK1 | PPP1R12A | Thr696 | ARQSRRStQGVTLTD | phosphorylation down-regulates | 8662509 | SIGNOR-42354 |
| LATS1 | PPP1R12A | Ser473 | GVTRSASsPRLSSSL | phosphorylation up-regulates activity | 22641346 | SIGNOR-278185 |
| ILK | PPP1R12A | Thr500 | RLAYVAPtIPRRLAS | phosphorylation down-regulates activity | 12030846 | SIGNOR-262884 |
| CHEK1 | PPP1R12A | Ser20 | QLKRWIGsETDLEPP | phosphorylation down-regulates quantity by destabilization | 29262732 | SIGNOR-277870 |
| ILK | PPP1R12A | Thr696 | ARQSRRStQGVTLTD | phosphorylation down-regulates | 12030846 | SIGNOR-87924 |
| NUAK1 | PPP1R12A | Ser445 | LGLRKTGsYGALAEI | phosphorylation down-regulates | 20354225 | SIGNOR-164747 |
| ROCK1 | PPP1R12A | Thr853 | PREKRRStGVSFWTQ | phosphorylation down-regulates activity | 10601309 | SIGNOR-249034 |
| ROCK2 | PPP1R12A | Thr853 | PREKRRStGVSFWTQ | phosphorylation down-regulates activity | 12220642 | SIGNOR-249164 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ILK | phosphorylation up-regulates → | PPP1R12A PThr710 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-87928 |
| ILK | phosphorylation up-regulates → | PPP1R12A PThr710 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-262885 |
| LATS1 | phosphorylation up-regulates → | PPP1R12A PSer445 | phosphorylation up-regulates → | PPP1R12A | 22641346 | SIGNOR-278184 |
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer910 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-22572 |
| ILK | phosphorylation up-regulates → | PPP1R12A PThr696 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-262886 |
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer472 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-164751 |
| ROCK1 | phosphorylation up-regulates → | PPP1R12A PThr696 | phosphorylation down-regulates ⊣ | PPP1R12A | 8662509 | SIGNOR-42354 |
| LATS1 | phosphorylation up-regulates → | PPP1R12A PSer473 | phosphorylation up-regulates → | PPP1R12A | 22641346 | SIGNOR-278185 |
| ILK | phosphorylation up-regulates → | PPP1R12A PThr500 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-262884 |
| CHEK1 | phosphorylation up-regulates → | PPP1R12A PSer20 | phosphorylation down-regulates ⊣ | PPP1R12A | 29262732 | SIGNOR-277870 |
| ILK | phosphorylation up-regulates → | PPP1R12A PThr696 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-87924 |
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer445 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-164747 |
| ROCK1 | phosphorylation up-regulates → | PPP1R12A PThr853 | phosphorylation down-regulates ⊣ | PPP1R12A | 10601309 | SIGNOR-249034 |
| ROCK2 | phosphorylation up-regulates → | PPP1R12A PThr853 | phosphorylation down-regulates ⊣ | PPP1R12A | 12220642 | SIGNOR-249164 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ILK | phosphorylation down-regulates | PPP1R12A | SIGNOR-87928 |
| ILK | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-262885 |
| LATS1 | phosphorylation → up-regulates activity | PPP1R12A | SIGNOR-278184 |
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-22572 |
| RAF1 | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-278979 |
| NUAK2 | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-279081 |
| ILK | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-262886 |
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-164751 |
| DAPK3 | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-279030 |
| ROCK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-42354 |
| LATS1 | phosphorylation → up-regulates activity | PPP1R12A | SIGNOR-278185 |
| ILK | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-262884 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | PPP1R12A | SIGNOR-277870 |
| ILK | phosphorylation down-regulates | PPP1R12A | SIGNOR-87924 |
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-164747 |
| ROCK1 | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-249034 |
| ROCK2 | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-249164 |
