| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NUAK1 | PPP1R12A | Ser445 | LGLRKTGsYGALAEI | phosphorylation down-regulates | 20354225 | SIGNOR-164747 |
| LATS1 | PPP1R12A | Ser445 | LGLRKTGsYGALAEI | phosphorylation up-regulates activity | 22641346 | SIGNOR-278184 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NUAK1 | phosphorylation up-regulates → | PPP1R12A PSer445 | phosphorylation down-regulates ⊣ | PPP1R12A | 20354225 | SIGNOR-164747 |
| LATS1 | phosphorylation up-regulates → | PPP1R12A PSer445 | phosphorylation up-regulates → | PPP1R12A | 22641346 | SIGNOR-278184 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NUAK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-164747 |
| LATS1 | phosphorylation → up-regulates activity | PPP1R12A | SIGNOR-278184 |
