| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ILK | PPP1R12A | Thr696 | ARQSRRStQGVTLTD | phosphorylation down-regulates | 12030846 | SIGNOR-87924 |
| ILK | PPP1R12A | Thr696 | ARQSRRStQGVTLTD | phosphorylation down-regulates activity | 12030846 | SIGNOR-262886 |
| ROCK1 | PPP1R12A | Thr696 | ARQSRRStQGVTLTD | phosphorylation down-regulates | 8662509 | SIGNOR-42354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ILK | phosphorylation up-regulates → | PPP1R12A PThr696 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-87924 |
| ILK | phosphorylation up-regulates → | PPP1R12A PThr696 | phosphorylation down-regulates ⊣ | PPP1R12A | 12030846 | SIGNOR-262886 |
| ROCK1 | phosphorylation up-regulates → | PPP1R12A PThr696 | phosphorylation down-regulates ⊣ | PPP1R12A | 8662509 | SIGNOR-42354 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ILK | phosphorylation down-regulates | PPP1R12A | SIGNOR-87924 |
| ILK | phosphorylation → down-regulates activity | PPP1R12A | SIGNOR-262886 |
| ROCK1 | phosphorylation down-regulates | PPP1R12A | SIGNOR-42354 |
