Entity Details

Name ROCK1_Thr853
ID O14974
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ROCK1PPP1R12AThr853PREKRRStGVSFWTQphosphorylation
down-regulates activity		10601309SIGNOR-249034
ROCK2PPP1R12AThr853PREKRRStGVSFWTQphosphorylation
down-regulates activity		12220642SIGNOR-249164
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ROCK1phosphorylation
up-regulates
→
PPP1R12A
PThr853		phosphorylation
down-regulates
⊣		PPP1R12A10601309SIGNOR-249034
ROCK2phosphorylation
up-regulates
→
PPP1R12A
PThr853		phosphorylation
down-regulates
⊣		PPP1R12A12220642SIGNOR-249164
Regulator Mechanism/Effect Target SIGNOR-ID
ROCK1phosphorylation
→
down-regulates activity 		PPP1R12ASIGNOR-249034
ROCK2phosphorylation
→
down-regulates activity 		PPP1R12ASIGNOR-249164