| Name | PER2 |
| ID | O15055 |
| Role | substrate |
| Enzymatic Domains |
PAS 1 181-248 PROSITE-ProRule
PAS 2 321-387 PROSITE-ProRule
PAC 395-438 |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | PER2 | – | phosphorylation down-regulates quantity by destabilization | 11165242 | SIGNOR-268000 | |
| CSNK1E | PER2 | – | phosphorylation down-regulates quantity by destabilization | 15767683 | SIGNOR-267995 | |
| SIK3 | PER2 | – | phosphorylation down-regulates quantity by destabilization | 29227248 | SIGNOR-279570 | |
| CSNK1E | PER2 | – | phosphorylation down-regulates quantity by destabilization | 17525164 | SIGNOR-276065 | |
| CSNK1E | PER2 | Ser480 | PVPHSGSsGYGSLGS | phosphorylation down-regulates quantity by destabilization | 30425162 | SIGNOR-277419 |
| CSNK1D | PER2 | Ser480 | PVPHSGSsGYGSLGS | phosphorylation down-regulates quantity by destabilization | 30425162 | SIGNOR-277420 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1E | phosphorylation up-regulates → | PER2 PSer480 | phosphorylation down-regulates ⊣ | PER2 | 30425162 | SIGNOR-277419 |
| CSNK1D | phosphorylation up-regulates → | PER2 PSer480 | phosphorylation down-regulates ⊣ | PER2 | 30425162 | SIGNOR-277420 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-268000 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-267995 |
| SIK3 | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-279570 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-276065 |
| CSNK1E | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-277419 |
| CSNK1D | phosphorylation down-regulates quantity by destabilization | PER2 | SIGNOR-277420 |