Summary

Name PER2
Full Name Period circadian protein homolog 2
Synonyms hPER2, Circadian clock protein PERIOD 2 | KIAA0347
Primary ID O15055
Links - -
Type protein
Relations 18
Pathways Circadian clock
Function Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PER2 0.491
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PER2 0.476
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding BMAL1/NPAS2 0.736
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TWIST1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER2 0.863
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.732
Publications: 1
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png binding POU2F1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.763
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.748
Publications: 1
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.315
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PER2 0.402
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER2 0.897
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PER2 0.461
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PER2 0.736
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CLOCK/BMAL1 0.757
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock